Design, synthesis, and biological activities of new thieno[3,2- d]pyrimidines as selective type 4 phosphodiesterase inhibitors

DOI: 10.1021/jm981012m

Source and publish data:

Journal of Medicinal Chemistry p. 4021 - 4035 (1998)

Update date:2022-07-29

Topics:

Authors:

Crespo, Maria I.

Pagès, Lluís

Vega, Armando

Segarra, Victor

López, Manel

Doménech, Teresa

Miralpeix, Montserrat

Beleta, Jordi

Ryder, Hamish

Palacios, José M.

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Article abstract of DOI:10.1021/jm981012m

A common pharmacophore for compounds structurally related to nitraquazone has been derived. Using this pharmacophore, new structures have been designed, synthesized, and evaluated for their inhibitory potencies against cyclic adenosine 5'-monophosphate (c

Full text of DOI:10.1021/jm981012m

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