Bioorganic and Medicinal Chemistry p. 5606 - 5618 (2008)
Update date:2022-07-30
Topics:
Chen, Chen
Tucci, Fabio C.
Jiang, Wanlong
Tran, Joe A.
Fleck, Beth A.
Hoare, Sam R.
Wen, Jenny
Chen, Takung
Johns, Michael
Markison, Stacy
Foster, Alan C.
Marinkovic, Dragan
Chen, Caroline W.
Arellano, Melissa
Harman, John
Saunders, John
Bozigian, Haig
Marks, Daniel
A series of 2-piperazine-α-isopropylbenzylamine derivatives were synthesized and characterized as melanocortin-4 receptor (MC4R) antagonists. Attaching an amino acid to benzylamines 7 significantly increased their binding affinity, and the resulting compo
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(2005)Doi:10.1021/acs.orglett.7b02552
(2017)Doi:10.1021/jo800514k
(2008)Doi:10.1016/S0040-4020(01)91420-6
(1985)Doi:10.1021/om800240w
(2008)
