PREPARATION D'ACYL-4-METHYLENE-3-TETRAHYDROFURANES: UN ACCES AUX α-METHYLENE-γ-LACTONES ET BUTENOLIDES FONCTIONNALISES

Article abstract of DOI:10.1016/S0040-4039(00)96032-5

The cohalogenation of α,β-unsaturated ketones 1 (a-j) by NBS in propargyl alcohol affords α-halo β-alcoxyketones 2 (a-j). Radical cyclisation of compounds 2 (a-j) gives rise to 4-acyl 3-methylene tetrahydrofurans 3 (a-j), according to a regio and diastere