Bioorganic and Medicinal Chemistry Letters p. 1871 - 1875 (2009)
Update date:2022-07-29
Topics:
Fish, Paul V.
Brown, Alan D.
Evrard, Edel
Roberts, Lee R.
New 7-sulfonamido-3-benzazepines 3 are disclosed as 5-HT2C receptor agonists. Appropriate substitution of the amino group (R1R2N-) gave compounds that were potent 5-HT2C agonists with minimal activation of the 5-HT2A and 5-HT2B receptors. Furthermore, representative examples had excellent in vitro ADME properties and good selectivity over ion channel activity.
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Doi:10.1016/S0040-4039(00)87832-6
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(2009)
