LATENT INHIBITORS. PART 4. IRREVERSIBLE INHIBITION OF DIHYDRO-OROTATE DEHYDROGENASE BY HYDANTOINS DERIVED FROM AMINO ACIDS

DOI: 10.1039/P19880003175

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 3175 - 3182 (1988)

Update date:2022-08-04

Topics:

Authors:

Buntain, Ian G.

Suckling, Colin J.

Wood, Hamish C. S.

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Article abstract of DOI:10.1039/P19880003175

Hydantoins and ureas derived from α-amino acids are shown to interact with dihydro-orotate dehydrogenase from Clostridium (Zymobacterium) oroticum, chiefly as weak competitive inhibitors but that the hydantoin derived from phenylalanine, 5-benzyl-3-(1-car

Full text of DOI:10.1039/P19880003175

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