Bioorganic and Medicinal Chemistry Letters p. 4729 - 4732 (2009)
Update date:2022-08-04
Topics:
Kobayashi, Kensuke
Tsujita, Tomohiro
Ito, Hirokatsu
Ozaki, Satoshi
Tani, Takeshi
Ishii, Yasuyuki
Okuda, Shoki
Tadano, Kiyoshi
Fukuroda, Takahiro
Ohta, Hisashi
Okamoto, Osamu
Structure-activity relationship studies directed toward improving the metabolic stability of compound 1 resulted in the identification of 3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyclopentyl]amino}methyl)-4-methyl-1H-pyrazol-1-yl]propanenitrile 39 (
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