Bioorganic and Medicinal Chemistry Letters p. 5851 - 5856 (2009)
Update date:2022-08-03
Topics:
Selness, Shaun R.
Devraj, Rajesh V.
Monahan, Joseph B.
Boehm, Terri L.
Walker, John K.
Devadas, Balekudru
Durley, Richard C.
Kurumbail, Ravi
Shieh, Huey
Xing, Li
Hepperle, Michael
Rucker, Paul V.
Jerome, Kevin D.
Benson, Alan G.
Marrufo, Laura D.
Madsen, Heather M.
Hitchcock, Jeff
Owen, Tom J.
Christie, Lance
Promo, Michele A.
Hickory, Brian S.
Alvira, Edgardo
Naing, Win
Blevis-Bal, Radhika
The identification and evolution of a series of potent and selective p38 inhibitors is described. p38 inhibitors based on a N-benzyl pyridinone high-throughput screening hit were prepared and their SAR explored. Their design was guided by ligand bound co-
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Doi:10.1016/S0040-4020(01)87722-X
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(2009)
