Bioorganic and Medicinal Chemistry Letters p. 2229 - 2233 (2010)
Update date:2022-08-05
Topics:
Cohen, Frederick
Koehler, Michael F.T.
Bergeron, Philippe
Elliott, Linda O.
Flygare, John A.
Franklin, Matthew C.
Gazzard, Lewis
Keteltas, Stephen F.
Lau, Kevin
Ly, Cuong Q.
Tsui, Vickie
Fairbrother, Wayne J.
A series of IAP antagonists based on thiazole or benzothiazole amide isosteres was designed and synthesized. These compounds were tested for binding to the XIAP-BIR3 and ML-IAP BIR using a fluorescence polarization assay. The most potent of these compound
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