Journal of the Chemical Society. Perkin transactions I p. 787 - 798 (1989)
Update date:2022-08-04
Topics:
Fishman, Andrew G.
Mallams, Alan K.
Rossman, Randall R.
Selective acylation techniques have been developed that enable the synthesis of 3-O-acetyl-4''-O-isovaleryltylosin and 3-O-acetyl-23-O-demycinosyl-4''-O-isovaleryltylosin to be carried out in an efficient manner starting from tylosin.The syntheses of the 2'-O-acetyl, 23-O-acetyl, and 2',23-di-O-acetyl derivatives of the latter are also described.The synthesis of key hydrazones is also described.The regio- and stereo-selective epoxidation of tylosin and its acyl derivatives afforded the 12,13-epoxyanalogues, which were used to synthesize novel acylated 12,13-epoxy derivatives of 23-O-demycinosyltylosin.
View MoreBasilea Pharmaceutica China Ltd.
Contact:+86-513-82198075
Address:No.638 Xiushan Road(East),Haimen, Jiangsu 226100, P.R.China
Contact:13357117572
Address:No.149 Shiji dadao Road.
Shanghai Mintchem Development ., Ltd
Contact:0086 21 5190 8570
Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
Yixing Bluwat Chemicals Co., Ltd.
Contact:+86 510 87821568
Address:Yongan Road, Yixing Chemical Industrial Park, Yixing, Jiangsu, China
Shanghai Biobond Pharmaceutical Co.,Ltd
website:http://www.sh-biobond.com/EnglishIndex.aspx
Contact:021-68719686 /18939786273/ 18917373795
Address:Shanghai Zhangjiang
Doi:10.1039/b926866a
(2010)Doi:10.1055/s-0029-1219274
(2010)Doi:10.1021/jo00280a050
(1989)Doi:10.1016/j.bmc.2010.03.019
(2010)Doi:10.1016/j.tetlet.2010.03.123
(2010)Doi:10.1021/ja00089a016
(1994)
