Journal of the Chemical Society. Perkin transactions I p. 787 - 798 (1989)
Update date:2022-08-04
Topics:
Fishman, Andrew G.
Mallams, Alan K.
Rossman, Randall R.
Selective acylation techniques have been developed that enable the synthesis of 3-O-acetyl-4''-O-isovaleryltylosin and 3-O-acetyl-23-O-demycinosyl-4''-O-isovaleryltylosin to be carried out in an efficient manner starting from tylosin.The syntheses of the 2'-O-acetyl, 23-O-acetyl, and 2',23-di-O-acetyl derivatives of the latter are also described.The synthesis of key hydrazones is also described.The regio- and stereo-selective epoxidation of tylosin and its acyl derivatives afforded the 12,13-epoxyanalogues, which were used to synthesize novel acylated 12,13-epoxy derivatives of 23-O-demycinosyltylosin.
View MoreSHAANXI TOP PHARM CHEMICAL CO.LTD
Contact:+86-029-85733403
Address:No.108 ,west sector,south er huan,xi'an,china
Nanjing Raise Pharmatech Co., Ltd
website:http://www.raisechem.com
Contact:+86-25-58649566
Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
Tianjin SPHINX SCIENTIFIC LAB.
Contact:+86-022-66211289
Address:Tianda high-tech Park. No.80,the 4th Avenue
Tianjin Ingenochem Technology Co.,Ltd
Contact:+86-22-23677060
Address:Hitech Green Industry Park K2-9-602, Nankai district
Contact:+86-10-67147360/67107388
Address:No.18 Guangming Zhongjie, Chongwen District, Beijing, 100061, China
Doi:10.1039/b926866a
(2010)Doi:10.1055/s-0029-1219274
(2010)Doi:10.1021/jo00280a050
(1989)Doi:10.1016/j.bmc.2010.03.019
(2010)Doi:10.1016/j.tetlet.2010.03.123
(2010)Doi:10.1021/ja00089a016
(1994)
