
Journal of Organic Chemistry p. 1471 - 1475 (1990)
Update date:2022-08-05
Topics: Synthesis Characterization Yield Novel Purification Reaction Conditions Preparation 4-substituted
Khanapure, Subhash P.
Biehl, Edward R.
The title compounds 20, 21, and 22 have been prepared in modest yields by a two-step reaction involving first the reaction of bromoarenes 3, 7, and 8 with lithioalkyl- and lithioarylacetonitriles under aryne-forming conditions.The cyano products 10, 14, and 16 so formed were then converted to the corresponding isochroman-3-ones by acidic hydrolysis.
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