SYNTHESIS OF THE ENANTIOMERS OF FELODIPINE AND DETERMINATION OF THEIR ABSOLUTE CONFIGURATION

DOI: 10.1016/S0040-4039(01)93912-7

Source and publish data:

Tetrahedron Letters p. 6423 - 6426 (1989)

Update date:2022-09-26

Topics:

Authors:

Lamm, Bo

Simonsson, Roger

Sundell, Staffan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(01)93912-7

The pure enantiomers of felodipine, 1, have been synthesized by chromatographic separation of diastereomeric esters with (R)-1-(p-toluenesulfonyl)-3-trityloxypropan-2-ol, 3, as an easily removable chiral auxiliary.Absolute configurations have been deduced

Full text of DOI:10.1016/S0040-4039(01)93912-7

Products guided by the article

Product name:(R)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-hydroxymethyl-2-(toluene-4-sulfonyl)-ethyl] ester

Cas No:127634-11-1

R&D Labs maybe for 127634-11-1

Jiangxi Dongbang Pharmaceutical Co., Ltd.

Contact:+86-795-4433603, 4433388

Address:Fengxin Industrial Park, Fengxin County, Jiangxi Province, P.R.C
Shanghai Profirst Co., Ltd.

Contact:+86-21-38122007

Address:2, Lane 1123, Kangqiao Road, Pudong New Area, Shanghai
Shanghai Rainbow Chemistry Co., Ltd.

Contact:+86-21-64968086-5815/5812

Address:3rd floor, Building 7, 251 Faladi Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai, P.R. China
LianYunGang Chiral Chemical(CHINA) CO.,LTD

Contact:+86-518-83616958 +86-519-82884848

Address:LianYunGang Chemical Industry Park (JiangSu)
Zhejiang Chemicals Import & Export Corporation (ZHECHEM)

Contact:+86-571-87046953

Address:No. 37, Qingchun Road

Relevant to this article

Synthesis and absolute configurations of the cytotoxic polyacetylenes isolated from the callus of Panax ginseng

Doi:10.1248/cpb.38.1447
(1990)
Enantioselective gold-catalyzed functionalization of unreactive sp ³ Ci-H bonds through a redox-neutral domino reaction

Doi:10.1002/chem.201100019
(2011)
Microwave-promoted efficient synthesis of dihydroquinazolines

Doi:10.1039/c0gc00838a
(2011)
Isolation of Exceptionally Persistent Nitrogen-centred Free Radicals: N-Arylthio-2,4,6-triphenylanilino Radicals

Doi:10.1039/c39900000441
(1990)
Efficient synthesis of 2-arylamino-2-imidazolines and 2-aminobenzimidazoles with aminoiminomethanesulfonic acid derivatives

Doi:10.1002/cjoc.201190179
(2011)
Enantioselective synthesis of oseltamivir phosphate

Doi:10.1016/j.tet.2011.01.064
(2011)

Article Doi