SYNTHESIS OF THE ENANTIOMERS OF FELODIPINE AND DETERMINATION OF THEIR ABSOLUTE CONFIGURATION

DOI: 10.1016/S0040-4039(01)93912-7

Source and publish data:

Tetrahedron Letters p. 6423 - 6426 (1989)

Update date:2022-09-26

Topics:

Authors:

Lamm, Bo

Simonsson, Roger

Sundell, Staffan

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Article abstract of DOI:10.1016/S0040-4039(01)93912-7

The pure enantiomers of felodipine, 1, have been synthesized by chromatographic separation of diastereomeric esters with (R)-1-(p-toluenesulfonyl)-3-trityloxypropan-2-ol, 3, as an easily removable chiral auxiliary.Absolute configurations have been deduced

Full text of DOI:10.1016/S0040-4039(01)93912-7

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