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Lower price of Propylparaben
Cas No: 94-13-3
USD $ 7.6-8.0 / Kilogram 1 Kilogram 500 Metric Ton/Month EAST CHEMSOURCES LIMITED Contact Supplier
Propylparaben CAS 94-13-3
Cas No: 94-13-3
No Data No Data No Data Wuxi TAA Chemical Industry Co.,LTD. Contact Supplier
Propyl 4-hydroxybenzoate
Cas No: 94-13-3
USD $ 20.0-30.0 / Gram 10 Gram 200 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Propylparaben
Cas No: 94-13-3
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality Propylparaben supplier in China
Cas No: 94-13-3
No Data 1 Kilogram 100 Metric Ton/Month Simagchem Corporation Contact Supplier
Propylparaben
Cas No: 94-13-3
USD $ 230.0-300.0 / Kilogram 1 Kilogram 100 Kilogram/Month Kono Chem Co.,Ltd Contact Supplier
high quality Nipasol (CAS# 94-13-3)
Cas No: 94-13-3
No Data 1 Kilogram 7000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
High quality Propylparaben Cas 94-13-3 with cheap price
Cas No: 94-13-3
USD $ 8.0-10.0 / Kilogram 25 Kilogram 300 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
High Quality 99% Propylparaben 94-13-3 GMP Manufacturer
Cas No: 94-13-3
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Supply Propylparaben
Cas No: 94-13-3
No Data 1 1 Ality Chemical Corporation Contact Supplier

94-13-3 Usage

Uses

An antimicrobial

storage

Aqueous propylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition.At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).

Uses

propylparaben is one of the most frequently used preservatives against bacteria and mold. It has a low sensitizing and low toxicity factor, is reputed to be very safe, and considered to be a noncomedogenic raw material.

Preparation

Produced by esterfying p-hydroxybenzoic acid with n-propanol, using an acid catalyst such as sulfuric acid and an excess of propanol. The materials are heated in a glass-lined reactor under reflux. The acid is then neutralized with caustic soda and the product is crystallized by cooling. The crystallized product is centrifuged, washed, dried under vacuum, milled and blended, all in corrosion-resistant equipment to avoid metallic contamination.

content analysis

Same with Method 1 in "Butyl p-hydroxybenzoate (07002)". In calculation, per mL of 1 mol/L sodium hydroxide corresponds to 180.2mg of this goods (C10Hl2O8).

Toxicity

Adl? 0-10 mg/kg (FAO/WHO, 2001). LD50? 3.7g/kg (mouse, oral). GRAS? (FDA, § 184.1670, 2000). HACSG? listed in the restricted list.

Aroma threshold values

Detection: 20 ppb

General Description

Colorless crystals or white powder or chunky white solid. Melting point 95-98°C. Odorless or faint aromatic odor. Low toxicity, Tasteless (numbs the tongue). pH: 6.5-7.0 (slightly acidic) in solution.

Contact allergens

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

usage limits

2760--2002 GB (calculate in p-hydroxybenzoic acid; g/kg): fresh fruit and vegetable 0.012; vinegar 0.10; carbonated beverages 0.20; fruit juice (fruit flavor) type beverages, jam (excluding canned), soy sauces 0.25; pastry stuffing 0.5 (the total amount of single use or mixed use with ethyl 4-hydroxybenzoate); egg yolk filling 0.20. Another provision that sodium methylparaben is also equivalent application. FAO/WHO (1984): Jam and jelly, 1000 mg/kg FDA § 184.1670 (2000): 0.1%. EEC(1990, mg/kg): Frozen drinks 160; beet pickled vegetables, salad dressings, 250; fragrance, fruit tarts, purees, concentrated soft drinks, 800; Fruit canned, salted fish, 1000. Japan (calculate in p-hydroxybenzoic acid, g/kg; this product, g): soy sauce 0.25g/L (this product 0.32); vinegarsoysoy 0.1g/L (This product 0.13); soft drinks and syrup 0.1 (this product 0.13); fruit sauce 0.2 (this product 0.26); fruits and vegetables 0.012 (this product 0.015).

Reactivity Profile

Maximum stability of Propylparaben occurs at a pH of 4 to 5. Incompatible with alkalis and iron salts. Also incompatible with strong oxidizing agents and strong acids .

Chemical properties

Propylparaben is a colorless and fine crystalline or white crystalline powder, almost odorless and with slightly astringent.Soluble in ethanol, ethyl ether, acetone and other organic solvents, slightly soluble in water.

Hazards & Safety Information

Category: Toxic substances Toxicity classification :Moderate toxicity Acute Toxicity :Celiac-mouse LD50: 200 mg/kg Flammable hazardous characteristics :Flammable; excrete acrid and pungent smoke from fire Storage and transport characteristics :Stored in the low-temperature, well-ventilated and dry warehouse Fire extinguishing agent :water, carbon dioxide, dry powder, sand

Chemical Properties

Propylparaben occurs as a white, crystalline, odorless, and tasteless powder.

Production Methods

Propylparaben is prepared by the esterification of p-hydroxybenzoic acid with n-propanol.

Fire Hazard

Flash point data for Propylparaben are not available; however, Propylparaben is probably combustible.

Incompatibilities

The antimicrobial activity of propylparaben is reduced considerably in the presence of nonionic surfactants as a result of micellization. Absorption of propylparaben by plastics has been reported, with the amount absorbed dependent upon the type of plastic and the vehicle. Magnesium aluminum silicate, magnesium trisilicate, yellow iron oxide, and ultramarine blue have also been reported to absorb propylparaben, thereby reducing preservative efficacy. Propylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Pharmaceutical Applications

Propylparaben is widely used as an antimicrobial preservative in cosmetics, food products, and pharmaceutical formulations. It may be used alone, in combination with other paraben esters, or with other antimicrobial agents. It is one of the most frequently used preservatives in cosmetics. The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds. Owing to the poor solubility of the parabens, the paraben salts, particularly the sodium salt, are frequently used in formulations. This may cause the pH of poorly buffered formulations to become more alkaline. Propylparaben (0.02% w/v) together with methylparaben (0.18% w/v) has been used for the preservation of various parenteral pharmaceutical formulations.

Air & Water Reactions

Water soluble [Hawley].

Chemical Properties

Propyl p-hydroxybenzoate is almost odorless.

Definition

ChEBI: The benzoate ester that is the propyl ester of 4-hydroxybenzoic acid. Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. Also used as a food additive.

Regulatory Status

Propylparaben and methylparaben are affirmed GRAS direct food substances in the USA at levels up to 0.1%. All esters except the benzyl ester are allowed for injection in Japan. In cosmetics, the EU and Brazil allow use of each paraben at 0.4%, but the total of all parabens may not exceed 0.8%. The upper limit in Japan is 1.0%. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM, IV, and SC injections; inhalations; ophthalmic preparations; oral capsules, solutions, suspensions, and tablets; otic, rectal, topical, and vaginal preparations). Included in parenteral and nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Safety

Propylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations. Propylparaben and methylparaben have been used as preservatives in injections and ophthalmic preparations; however, they are now generally regarded as being unsuitable for these types of formulations owing to the irritant potential of the parabens. Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. The WHO has set an estimated acceptable total daily intake for methyl, ethyl, and propyl parabens at up to 10 mg/kg body-weight. LD50 (mouse, IP): 0.2 g/kg LD50 (mouse, oral): 6.33 g/kg LD50 (mouse, SC): 1.65 g/kg

Chemical Properties

White or almost white, crystalline powder.

Uses

1. Propylparaben Used as preservatives and antioxidants, and also used in the pharmaceutical industry 2. Used as the antimicrobial preservative in pharmaceuticals and cosmetics 3. According to ethyl p-hydroxybenzoate (17007) 4. Used as antiseptic and antimicrobial. 5. Used as the preservatives of food, cosmetics and medicines.

Uses

Pharmaceutic aid (antifungal). Antimicrobial preservative in foods and cosmetics.

Production methods

This product can be derived from the esterification of p-hydroxybenzoic acid and n-propanol. First mix p-hydroxybenzoic acid with propanol and heat to dissolve. Then add sulfuric acid slowly and continue to heat for 8h of refluxion. After cooling, pour them into the 4% sodium carbonate solution for precipitation and crystallization. Filtrate and wash to neutral to obtain the crude product. After further ethanol recrystallization, the finished products are obtained. In the preparation, the cation exchange resin can be used in place of the sulfuric acid catalyst. It can be derived from the esterification of p-hydroxybenzoic acid and n-propanol in the presence of sulfuric acid. Add p-hydroxybenzoic acid and n-propanol in turn to the esterification reactor, and heat to dissolve. Add concentrated sulfuric acid slowly and heat for 8h of refluxion. Pour the reaction solution into 4% sodium carbonate solution before it is cooled. Constantly stir for precipitation and crystallization. Then the crude product can be obtained after centrifugal filtration and washed to neutral. Finally the finished product is acquired after activated carbon decolorization and ethanol recrystallization. The method of preparing ethyl p-hydroxybenzoate can also be used as a reference. HOC6H4COOH + C3H7OH [H2SO4] → HOC6H4COOC3H7 + H2O
InChI:InChI=1/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3

94-13-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A10180)  n-Propyl 4-hydroxybenzoate, 99+%    94-13-3 250g 421.0CNY Detail
Alfa Aesar (A10180)  n-Propyl 4-hydroxybenzoate, 99+%    94-13-3 1000g 1076.0CNY Detail
Alfa Aesar (A10180)  n-Propyl 4-hydroxybenzoate, 99+%    94-13-3 5000g 4706.0CNY Detail
Sigma-Aldrich (PHR1010)  Propylparaben  pharmaceutical secondary standard; traceable to USP and PhEur 94-13-3 PHR1010-1G 732.19CNY Detail
Sigma-Aldrich (PHR1010)  Propylparaben  pharmaceutical secondary standard; traceable to USP and PhEur 94-13-3 PHR1010-10G 4,312.04CNY Detail
Sigma-Aldrich (P3650000)  Propyl parahydroxybenzoate  European Pharmacopoeia (EP) Reference Standard 94-13-3 P3650000 1,880.19CNY Detail
USP (1577008)  Propylparaben  United States Pharmacopeia (USP) Reference Standard 94-13-3 1577008-200MG 4,662.45CNY Detail

94-13-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name propylparaben

1.2 Other means of identification

Product number -
Other names Nipazol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food Additives: PRESERVATIVE
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:94-13-3 SDS

94-13-3Synthetic route

n-propyl 4-acetoxybenzoate
27739-13-5

n-propyl 4-acetoxybenzoate

nipasol
94-13-3

nipasol

Conditions
ConditionsYield
With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 90℃; for 0.5h;95%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 3h;79%
propan-1-ol
71-23-8

propan-1-ol

4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

nipasol
94-13-3

nipasol

Conditions
ConditionsYield
With methanesulfonic acid; choline chloride Reflux;93.4%
With benzimidazole bisulfate ionic liquid Reflux;93.8%
With NKC-9-type macroporous resin at 98℃; for 3.08333h; Temperature; Microwave irradiation;89%
n-propyl 4-benzoyloxybenzoate

n-propyl 4-benzoyloxybenzoate

nipasol
94-13-3

nipasol

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 3h;90%
With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 90℃; for 0.5h;90%
With potassium fluoride; thiophenol In 1-methyl-pyrrolidin-2-one at 100℃; for 1h;80%
1-(tert-butyldimethylsilyloxy)-2-propane
17348-67-3

1-(tert-butyldimethylsilyloxy)-2-propane

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

nipasol
94-13-3

nipasol

Conditions
ConditionsYield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; Selectfluor In acetonitrile at 20℃; for 7h; Inert atmosphere; Irradiation;80%
propan-1-ol
71-23-8

propan-1-ol

tetrachloromethane
56-23-5

tetrachloromethane

phenol
108-95-2

phenol

A

nipasol
94-13-3

nipasol

B

propyl salicylate
607-90-9

propyl salicylate

Conditions
ConditionsYield
With diiron nonacarbonyl at 130℃; for 6h; Catalytic behavior; Reagent/catalyst; Time; Inert atmosphere; Sealed tube;A 66%
B 34%
With iron(II) bromide at 130℃; for 6h; Reagent/catalyst; Inert atmosphere; Sealed tube;A 20%
B 22%
propan-1-ol
71-23-8

propan-1-ol

carbon monoxide
201230-82-2

carbon monoxide

phenol
108-95-2

phenol

nipasol
94-13-3

nipasol

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; oxygen; potassium carbonate; potassium iodide at 100℃; under 6000.6 Torr; for 18h;50%
carbon dioxide
124-38-9

carbon dioxide

tetrapropyl-ammonium; phenolate

tetrapropyl-ammonium; phenolate

A

nipasol
94-13-3

nipasol

B

4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

Conditions
ConditionsYield
With potassium carbonate at 125℃; under 37503 Torr; for 2h; Kolbe-Shmitt reaction;A 3.1 % Chromat.
B 30 % Chromat.

94-13-3Upstream product

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