Stereoselective Synthesis of 3-Amino 1,2-Diols via Intermolecular Pinacol Cross-Coupling of α-Aldehydes with Aliphatic Aldehydes. Short Asymmetric Syntheses of Two 2,3,6-Trideoxy-3-amino Sugars

Article abstract of DOI:10.1021/jo00302a005

syn,syn-3-Amino 1,2-diols are prepared via a pinacol cross coupling reaction between N-Cbz- or N-Boc-α-amino aldehydes and aliphatic aldehydes.Application of this methodology to the synthesis of two amino sugars starting from N-Cbz-L-aspartic acid are described.