9004-64-2 Usage
Description
Different sources of media describe the Description of 9004-64-2 differently. You can refer to the following data:
1. Hydroxypropyl cellulose (HPC) is a derivative of cellulose being soluble in both water and organic acid. It is excellent in trapping water and preventing water loss. It can be used to treat diseases associated with insufficient tear production such as keratoconjunctivitis sicca, recurrent corneal erosions, decreased corneal sensitivity, and exposure and neuroparalytic keratitis. It is also used as a lubricant of artificial eyes. It can also be used as a thickener, an emulsion stabilizer and binder. Moreover, it can be used as a sieving matrix for DNA separation through capillary and microchip electrophoresis. It is also the major ingredient of Cellugel, which is used in book conservation.
2. Hydroxypropyl cellulose is a cellulose ether containing hydroxypropyl substitution. It occurs as a white powder. It is soluble in
water and in certain organic solvents. It may contain a suitable
anticaking agent.
References
https://www.drugbank.ca/drugs/DB00840
https://en.wikipedia.org/wiki/Hydroxypropyl_cellulose
Chemical Properties
Different sources of media describe the Chemical Properties of 9004-64-2 differently. You can refer to the following data:
1. White or yellowish-white powder or granules, hygroscopic after drying
2. Hydroxypropyl cellulose is a white to slightly yellow-colored,
odorless and tasteless powder.
Originator
Lacrisert,MSD,US,1981
Uses
Different sources of media describe the Uses of 9004-64-2 differently. You can refer to the following data:
1. Hydroxypropyl Cellulose is a gum that is nonionic water-soluble
cellulose, obtained from the reaction of alkali cellulose with propyl-
ene oxide at high temperatures and pressures. it is soluble in water
below 40°c, is precipitated as a floc between 40°c and 45°c, and is
insoluble above 45°c. the precipitation is reversible with the origi-
nal viscosity being restored upon cooling below 40°c and stirring. it
is used in whipped toppings as a stabilizing and foaming aid; in
edible food coatings as a glaze and oil/oxygen barrier; and in fabri-
cated foods as a binder. typical usage level is 0.05–1.0%.
2. Hydroxypropyl Cellulose is used in the synthesis of nanoparticle carriers for drug delivery.
3. As emulsifier, stabilizer, whipping aid, protective colloid, film former or thickener in foods; as binder in ceramics and glazes; in hair and cosmetic Preparations; in vacuum-formed containers and blow-molded bottles; as suspending agent in PVC polymerization. Pharmaceutic aid (tablet coating agent).
Definition
A cellulose ether with hydroxypropyl substitution.
Production Methods
A purified form of cellulose is reacted with sodium hydroxide to
produce a swollen alkali cellulose that is chemically more reactive
than untreated cellulose. The alkali cellulose is then reacted with
propylene oxide at elevated temperature and pressure. The
propylene oxide can be substituted on the cellulose through an
ether linkage at the three reactive hydroxyls present on each
anhydroglucose monomer unit of the cellulose chain. Etherification
takes place in such a way that hydroxypropyl substituent groups
contain almost entirely secondary hydroxyls. The secondary
hydroxyl present in the side chain is available for further reaction
with the propylene oxide, and ‘chaining-out’ may take place. Thisresults in the formation of side chains containing more than 1 mole
of combined propylene oxide.
Manufacturing Process
Charge:Procedure:
The tertiary butanol, water and sodium hydroxide were mixed and the mixture
cooled to 20°C. The purified cotton linters were added to the mixture and
aged at 20°C for one hour while stirring. Excess liquid was filtered off the
resulting alkali cellulose so that the resulting alkali cellulose filter cake
weighed 3.08 parts. This filter cake was broken up and slurried in the hexane,
placed in a pressure vessel the pressure of which was increased to 100 psig
with nitrogen, and then the pressure was vented to 5 psig. The propylene
oxide was added to the pressure vessel and then the pressure was increased
to 25 psig with nitrogen. The resulting charge was heated to 85°C in 30
minutes and then reacted at this temperature and 25 psig pressure for six
hours. The charge was cooled to 30°C. the pressure vessel vented and 0.14
part of glacial acetic acid added. The excess hexane was filtered off from the
resulting hydroxypropyl cellulose product, the product was purified by washing
with hot water (85°C to 95°C) and then dried at 130°C using a two-roll drum
drier.
Therapeutic Function
Topical protectant, Ophthalmic vehicle
General Description
Hydroxypropyl cellulose (HPC) is biocompatible in nature and exhibits low critical solution temperature (LCST). It has been reported to be prepared by reacting cellulose with alkali, producing alkali cellulose which is consecutively reacted with propylene oxide. HPC is soluble in water at lower than RT. Viscosity behaves inversely to rise in temperature.
Pharmaceutical Applications
Hydroxypropyl cellulose is widely used in oral and topical pharmaceutical formulations.
In oral products, hydroxypropyl cellulose is primarily used in tableting as a binder,film-coating,and extended-release-matrix former. Concentrations of hydroxypropyl cellulose of 2–6% w/w may be used as a binder in either wet-granulation or dry, direct compression tableting processes. Concentrations of 15–35% w/w of hydroxypropyl cellulose may be used to produce tablets with an extended drug release. The release rate of a drug increases with decreasing viscosity of hydroxypropyl cellulose. The addition of an anionic surfactant similarly increases the viscosity of hydroxypropyl cellulose and hence decreases the release rate of a drug. Blends of hydroxypropyl cellulose and other cellulosic polymers have been used to improve wet granulation characteristics and tableting characteristics, as well as to achieve better control and manipulation of the rate of drug release. As an alternative technology to wet granulation, dry granulation and direct compression of hydroxypropyl cellulose formulations have been reported to exhibit acceptable tableting and flow characteristics for application in extended-release matrix tablets. Typically, a 5% w/w solution of hydroxypropyl cellulose may be used to film-coat tablets. Aqueous solutions containing hydroxypropyl cellulose together with an amount of methyl cellulose or ethanolic solutions have been used. Stearic acid or palmitic acid may be added to ethanolic hydroxypropyl cellulose solutions as plasticizers. Environmental concerns have limited the use of ethanol in film coating solutions. A low-substituted hydroxypropyl cellulose is used as a tablet disintegrant; see Hydroxypropyl Cellulose, Low-substituted.
Hydroxypropyl cellulose is also used in microencapsulation processes and as a thickening agent. In topical formulations, hydroxypropyl cellulose is used in transdermal patches and ophthalmic preparations.
Hydroxypropyl cellulose is also used in cosmetics and in food products as an emulsifier and stabilizer.
Safety
Hydroxypropyl cellulose is widely used as an excipient in oral and
topical pharmaceutical formulations. It is also used extensively in
cosmetics and food products.
Hydroxypropyl cellulose is generally regarded as an essentially
nontoxic and nonirritant material. It is not absorbed from the
gastrointestinal tract and is fully recovered in feces after oral
administration in rats. It does not exhibit skin irritation or skin
sensitization. However, the use of hydroxypropyl cellulose as a solid
ocular insert has been associated with rare reports of discomfort or
irritation, including hypersensitivity and edema of the eyelids.
Adverse reactions to hydroxypropyl cellulose are rare. However, it
has been reported that a single patient developed contact dermatitis
due to hydroxypropyl cellulose in a transdermal estradiol patch.
The WHO has specified an acceptable daily intake for
hydroxypropyl cellulose of up to 1500 mg/kg body-weight.
Excessive consumption of hydroxypropyl cellulose may have a
laxative effect.
LD50 (rat, IV): 0.25 g/kg
LD50 (rat, oral): 10.2 g/kg
storage
Hydroxypropyl cellulose powder is a stable material, although it is
hygroscopic after drying.
Aqueous solutions of hydroxypropyl cellulose are stable at pH
6.0–8.0, with the viscosity of solutions being relatively unaffected.
However, at low pH aqueous solutions may undergo acid
hydrolysis, resulting in chain scission and hence a decrease in
solution viscosity. The rate of hydrolysis increases with increasing
temperature and hydrogen ion concentration. At high pH, alkalicatalyzed
oxidation may degrade the polymer and result in a
decrease in viscosity of solutions. This degradation can occur owing
to the presence of dissolved oxygen or oxidizing agents in a
solution.
Increasing temperature causes the viscosity of aqueous solutions
to decrease gradually until the viscosity drops suddenly at about
45°C owing to the limited solubility of hydroxypropyl cellulose.
However, this process is reversible and on cooling the original
viscosity is restored.
The high level of substitution of hydroxypropyl cellulose
improves the resistance of the polymer to degradation by molds
and bacteria. However, aqueous solutions are susceptible to
degradation under severe conditions and a viscosity decrease may
occur. Certain enzymes produced by microbial action will degrade
hydroxypropyl cellulose in solution. Therefore, for prolonged
storage, an antimicrobial preservative should be added to aqueous
solutions. Solutions of hydroxypropyl cellulose in organic solvents
do not generally require preservatives.
Ultraviolet light will also degrade hydroxypropyl cellulose and
aqueous solutions may therefore decrease slightly in viscosity if
exposed to light for several months.
Aqueous hydroxypropyl cellulose solutions have optimum
stability when the pH is maintained at 6.0–8.0, and also when the
solution is protected from light, heat, and the action of microorganisms.
Hydroxypropyl cellulose powder should be stored in a wellclosed
container in a cool, dry place.
Incompatibilities
Hydroxypropyl cellulose in solution demonstrates some incompatibility
with substituted phenol derivatives, such as methylparaben
and propylparaben. The presence of anionic polymers may increase
the viscosity of hydroxypropyl cellulose solutions.
The compatibility of hydroxypropyl cellulose with inorganic
salts varies depending upon the salt and its concentration. Hydroxypropyl cellulose may not tolerate high concentrations
of other dissolved materials.
The balance of the hydrophilic–lipophilic properties of the
polymer, which are required for dual solubility, reduces its ability to
hydrate with water and it therefore tends to be salted out in the
presence of high concentrations of other dissolved materials.
The precipitation temperature of hydroxypropyl cellulose is
lower in the presence of relatively high concentrations of other
dissolved materials that compete for the water in the system;
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (oral capsules
and tablets; topical and transdermal preparations). Included in
nonparenteral medicines licensed in the UK. Included in the
Canadian List of Acceptable Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 9004-64-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 9004-64:
(6*9)+(5*0)+(4*0)+(3*4)+(2*6)+(1*4)=82
82 % 10 = 2
So 9004-64-2 is a valid CAS Registry Number.
InChI:InChI=1/C36H70O19/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41/h19-44H,9-18H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27?,28?,29?,30-,31?,32?,33?,34?,35?,36+/m1/s1
9004-64-2Relevant articles and documents
Solid dosage form comprising solid dispersion and method for producing the same
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Page/Page column 9, (2008/06/13)
Provided are a solid dosage form comprising a solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising a solid dispersion, the dispersion comprising: a poorly soluble drug, a water-soluble polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g. Moreover, provided is a method for producing a solid dosage form comprising a solid dispersion, the method comprising steps of: spraying a water-soluble polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g and serving as a disintegrant and granulating the resultant; and drying.
