European Journal of Medicinal Chemistry p. 267 - 270 (1990)
Update date:2022-07-29
Topics:
Melikian
Boigegrain
Kan
Soubrie
In the kynurenine metabolic pathways of tryptophan in kidney, liver and brain, 3-hydroxyanthranilic oxygenase (3-HAO, EC 1.13.11.6) catalyses the conversion of 3-hydroxyanthranilic acid to quinolinic acid, an excitatory amino acid putatively involved in brain neurodegenerative disorders. The compound 4-chloro-3-hydroxyanthranilic acid is an irreversible inhibitor of 3-HAO in the liver and the kidney. We describe here a new, unambiguous regioselective synthesis of this inhibitor and verify its activity on 3-HAO at the brain level.
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Doi:10.1055/s-0030-1259304
(2011)Doi:10.1016/S0040-4020(01)82038-X
(1990)Doi:10.1248/cpb.39.1253
(1991)Doi:10.1021/ja00176a073
(1990)Doi:10.1055/s-1993-25982
(1993)Doi:10.1016/S0040-4039(00)94719-1
(1990)
