Renin Inhibitors Containing Conformationally Restricted P1-P1' Dipeptide Mimetics

DOI: 10.1021/jm00107a004

Source and publish data:

Journal of Medicinal Chemistry p. 887 - 900 (1991)

Update date:2022-08-05

Topics:

Authors:

Williams, Peter D.

Perlow, Debra S.

Payne, Linda S.

Holloway, M. Katharine

Siegl, Peter K. S.

et al. et al.

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Article abstract of DOI:10.1021/jm00107a004

A series of renin inhibitors containing lactam-bridged P₁-P₁' dipeptide mimetics based on the ACHPA (4(S)-amino-5-cyclohexyl-3(S)-hydroxypentanoic acid) design was studied.The inhibitors were obtained by aldol addition of various lac

Full text of DOI:10.1021/jm00107a004

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