Communications
complexes. Significantly, the 13C chemical shifts determined
for the C(21) atoms of 3 (d = 22.3 ppm), 4 (d = 59.9 ppm), 5
(d = 34.0 ppm), and 6 (d = 14.2 ppm) reflect the tetrahedral
geometry around the coordinating carbon atom.
The coordination environment of the palladium(II) center
corresponds to the conventional square-planar structure with
the N(22), N(23), N(24), and C(21) atoms occupying equa-
torial positions. The macrocycle reveals the bond-length
pattern expected for the aromatic 21-carbaporphyrin.[15] The
specific localization of the 21-formyl substituent results in the
relatively short Pd···C(formyl) distance (2.531(2) ꢀ). Signifi-
cantly, in spite of the intensive exploration of metallocarba-
porphyrinoids, 4 (Figure 5) and 5 are the very first represen-
tatives of 21-carbaporphyrin complexes.[13,15,23–25]
Scheme 4. Addition to 2. Reaction conditions: a) sodium borohydride,
methanol, b) sodium borodeuteride, [D4]methanol, and c) sodium
ethoxide in ethanol.
addition of alkoxides is reversible as 2 forms from 7 during
column chromatography on silica gel. The addition of the
ethoxide ion to form 7 competes with the reduction of 2 to
form 6-H. The ethoxide ion in ethanol acted as the reducing
agent, as equimolar amounts of 6-H and ethanal were
1
detected by H NMR spectroscopy in the reaction mixture
(Figure S5).
In conclusion, palladium(II) p-benziporphyrin provides a
unique environment to alter the fundamental reactivity of the
benzene unit. The possibility of a metal···(carbon–carbon)
interaction by encapsulating the specific donor center
(CCNNN) in the porphyrinic core is of fundamental
importance.[12,17,18] By taking advantage of the additional
stabilization that arises from geometrical constraints of the
porphyrin macrocycle, a cascade of intramolecular rearrange-
ments has been efficiently promoted. Accordingly, the
remarkable, facile palladium(II)-mediated contraction of p-
phenylene to cyclopentadiene affords the first reported
complex of 21-carbaporphyrin.
Figure 5. Crystal structure of 4 (top: perspective view, bottom: side
view with phenyl groups omitted for clarity). Thermal ellipsoids
represent 50% probability. Selected bond lengths [ꢀ]: Pd–N(22)
2.012(2), Pd–N(23) 2.048(2), Pd–N(24) 2.023(2), Pd–C(21) 2.084(2).
The side view shows the geometry of interaction between palladium(II)
and the formyl substituent.
A feasible mechanism of contraction consistent with
formation of 3, 4, and 5 is shown in Scheme 3 and comprise
the following major steps: 1) addition of palladium(II) and a
hydroxide ion to the C(21)–C(22) double bond,[26] 2) b elimi-
nation,[27] and 3) competing contractions by 1,2-hydride shift
or cheletropic extrusion of carbon oxide. The contraction is
accompanied by a relief of strain energy of the embedded
conjugated 1,3-cyclohexadiene ring and finally by the for-
mation of a new aromatic porphyrinoid system.
Received: March 30, 2011
Published online: May 31, 2011
À
Keywords: C C activation · carbaporphyrinoids · palladium ·
porphyrinoids · ring contraction
.
Activation of the p-phenylene moiety of 2 toward a
combined addition of palladium(II) and a nucleophile of
choice is of particular importance and has been proven to be a
more general reactivity route. In fact, reaction of 2 with
sodium borohydride (in methanol), sodium borodeuteride (in
[D4]methanol), and sodium ethoxide afforded 6-H, 6-D, and 7
respectively (Scheme 4). Significantly, 6 and 7 do not undergo
further conversion, thus directly confirming the unique role of
the hydroxy group in the contraction mechanism. The
[1] a) M. Luria, G. Stein, Chem. Commun. 1970, 1650 – 1651; b) L.
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ꢀ 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Angew. Chem. Int. Ed. 2011, 50, 6587 –6591