Peptide/laccase cocatalyzed asymmetric α-oxyamination of aldehydes

Article abstract of DOI:10.1021/ol2012956

An asymmetric α-oxyamination could be successfully performed by a peptide catalyst and laccase. The combination of peptide catalysis and enzymatic air oxidation promoted the reaction smoothly in water without employing a metal reagent. The oxyaminated compounds could be obtained as both aldehyde and carboxylic acid products depending on the reaction conditions.