A NOVEL ONE-POT SYNTHESIS OF TRIFLUOROMETHYLATED β,γ-UNSATURATED ESTERS AND NITRILES

Article abstract of DOI:10.1016/S0022-1139(00)80190-6

Trifluoromethylated β,γ-unsaturated esters and nitriles can be synthesized by reaction of organozinc compounds with fluorinated β-ketophosphonium salts.This novel reaction without isolation of intermediates provides a convenient synthesis of the title compounds which may be useful intermediates for the preparation of fluorinated biologically active compounds.