Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation

DOI: 10.1021/jm00081a021

Source and publish data:

Journal of Medicinal Chemistry p. 573 - 583 (1992)

Update date:2022-08-05

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Authors:

Dore Dore

Gilbert Gilbert

Bignon Bignon

De Paulet

Ojasoo Ojasoo

Pons Pons

Raynaud Raynaud

Miquel Miquel

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Article abstract of DOI:10.1021/jm00081a021

The response profiles of 36 para-substituted diphenylethylenes (DPEs) and triphenylacrylonitriles (TPEs) have been compared by multivariate analysis. The responses measured were (a) relative binding affinity (RBA) for the cytosol estrogen receptor (ER), (

Full text of DOI:10.1021/jm00081a021

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