Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation

DOI: 10.1021/jm00081a021

Source and publish data:

Journal of Medicinal Chemistry p. 573 - 583 (1992)

Update date:2022-08-05

Topics:

Authors:

Dore Dore

Gilbert Gilbert

Bignon Bignon

De Paulet

Ojasoo Ojasoo

Pons Pons

Raynaud Raynaud

Miquel Miquel

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00081a021

The response profiles of 36 para-substituted diphenylethylenes (DPEs) and triphenylacrylonitriles (TPEs) have been compared by multivariate analysis. The responses measured were (a) relative binding affinity (RBA) for the cytosol estrogen receptor (ER), (

Full text of DOI:10.1021/jm00081a021

Products guided by the article

Product name:2-[4-(2-Diisopropylamino-ethoxy)-phenyl]-3,3-diphenyl-acrylonitrile

Cas No:137743-25-0

R&D Labs maybe for 137743-25-0

Lian Xing Chemical Co.,Ltd.

Contact:0792-8228321

Address:10TH Floor No.121 binjiang Road Xunyang District
Watson International Ltd

Contact:+44 (0)2036089360-31

Address:Chanceryhouse,Chancery Lan
Shanghai Rich Chemicals Co., Ltd

website:http://www.richchemical.com

Contact:+86-21-20255798

Address:Pudong Shanghai,China
Kono Chem Co.,Ltd

website:http://www.konochem.com

Contact:86-29-86107037

Address:No.170 West Avenue,Xi’an 710082,China
Hebei DaPeng Pharm & Chem Co., Ltd.

Contact:86-317-7298678,0576-88861898 88861908

Address:West Songmen Village, East Songmen Town, Wuqiao, Cangzhou, Hebei ,China

Relevant to this article

Highly regio-and enantioselective synthesis of polysubstituted 2 H -pyrroles via pd-catalyzed intermolecular asymmetric allylic dearomatization of pyrroles

Doi:10.1021/ja5028138
(2014)
Doi:10.1039/j39670000400
(1967)
New homocamptothecins: Synthesis, antitumor activity, and molecular modeling

Doi:10.1016/j.bmc.2007.10.046
(2008)
N-Heterocyclic Carbene-Catalyzed Synthesis of α-Trifluoromethyl Esters

Doi:10.1021/acs.orglett.8b01482
(2018)
The three-component biginelli reaction: A combined experimental and theoretical mechanistic investigation

Doi:10.1002/chem.200900470
(2009)
REARRANGEMENT OF 1-OXA-2-AZOLES. 4. SYNTHESIS AND REARRANGEMENT OF ISOXAZOLE- AND 4,5-DIHYDROISOXAZOLE-3-CARBOXYLIC ACID AMIDOXIMES

Doi:10.1007/BF00472518
(1991)

Article Doi