Welcome to LookChem.com Sign In|Join Free
  • or

71-30-7

Post Buying Request

71-30-7 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Cytosine Anabolic Pharmaceuticals High Purity Lamivudine Intermediates CAS 71-30-7
Cas No: 71-30-7
No Data 100 Gram 20000 Kilogram/Day Hubei XinRunde Chemical Co., Ltd Contact Supplier
Cytosine
Cas No: 71-30-7
No Data No Data Metric Ton/Day Shandong Xinhua Pharmaceutical Co.,Ltd Contact Supplier
Cytosine Manufacturer/High quality/Best price/In stock
Cas No: 71-30-7
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality Cytosine supplier in China
Cas No: 71-30-7
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
High purity Various Specifications Cytosine CAS:71-30-7
Cas No: 71-30-7
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Cytosine
Cas No: 71-30-7
USD $ 10.0-10.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
Cytosine
Cas No: 71-30-7
USD $ 1.0-2.0 / Metric Ton 1 Metric Ton 500 Metric Ton/Week Hebei yanxi chemical co.,LTD. Contact Supplier
High Quality 99% Cytosine 71-30-7 GMP manufacturer
Cas No: 71-30-7
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Cytosine
Cas No: 71-30-7
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory Supply Cytosine
Cas No: 71-30-7
No Data 1 1 Ality Chemical Corporation Contact Supplier

71-30-7 Usage

Definition

cytosine: A pyrimidine derivative.It is one of the principal componentbases of nucleotides and the nucleicacids DNA and RNA.

History

Cytosine is first isolated by hydrolysis of calf thymus tissue by Albrecht Kossel (1853–1927) and A. Neumann during 1893–1894. Thymine’s structure was published in 1900 and confi rmed over the next several years when it was synthesized by several investigators. In 1903, cytosine was synthesized by Henry Lord Wheeler (1867–1914) and Treat B. Johnson, confirming its structure. Uracil was first isolated in 1900 from yeast nucleic acid found in bovine thymus and herring sperm.the methylation of uracil produces thymine; thymine is also called 5-methyluracil because methylation takes place at the fi fth carbon in uracil to produce thymine.

Uses

Widely distributed in nature; constituent of nucleic acids

Definition

A nitrogenous base found in DNA and RNA. Cytosine has the pyrimidine ring structure.

Purification Methods

Cytosine crystallises from H2O as the monohydrate which loses water on heating above 100o. Its solubility in H2O is 0.77%. UV: max 267nm ( 6,100) in H2O pH 8.8 and 275nm ( 10,400) in 0.1N HCl. [Hilbert & Johnson J Am Chem Soc 52 1152 1930, Hilbert et al. J Am Chem Soc 57 552 1935, Beistein 25 III/IV 3654.]

Description

Cytosine is pyrimidine; along with adenine and guanine they account for the fi ve nucleic acid bases. Pyrimidines are heterocyclic single-ringed compounds based on the structure of pyrimidine. Cytosinelike adenine and guanine, form nucleosides and nucleotides in RNA and DNA. When the bases combine with ribose, a ribonucleoside forms; and when it attaches to deoxyribose, a deoxyribosenucleoside is formed. Names of the nucleoside are summarized in Table 29.1.these in turn combine with phosphoryl groups, in a process called phosphorylation, to form their respective nucleotides that form nucleic acids.the nucleotides can be tri, di, and mono phosphate nucleotides similar to the way in which adenine forms ATP, ADP, and AMP.

Chemical Properties

White Solid

Definition

ChEBI: An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4.
InChI:InChI=1/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)

71-30-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (C0528)  Cytosine  >98.0%(HPLC)(T) 71-30-7 5g 345.00CNY Detail
TCI America (C0528)  Cytosine  >98.0%(HPLC)(T) 71-30-7 25g 890.00CNY Detail
TCI America (C0528)  Cytosine  >98.0%(HPLC)(T) 71-30-7 100g 2,450.00CNY Detail
Alfa Aesar (A14731)  Cytosine, 98+%    71-30-7 5g 480.0CNY Detail
Alfa Aesar (A14731)  Cytosine, 98+%    71-30-7 25g 1792.0CNY Detail
Alfa Aesar (A14731)  Cytosine, 98+%    71-30-7 100g 6092.0CNY Detail
Sigma-Aldrich (PHR1350)  Cytosine  pharmaceutical secondary standard; traceable to USP 71-30-7 PHR1350-500MG 732.19CNY Detail
Sigma-Aldrich (Y0000676)  Gemcitabine impurity A  European Pharmacopoeia (EP) Reference Standard 71-30-7 Y0000676 1,880.19CNY Detail
USP (1162148)  Cytosine  United States Pharmacopeia (USP) Reference Standard 71-30-7 1162148-100MG 4,662.45CNY Detail

71-30-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name cytosine

1.2 Other means of identification

Product number -
Other names 2(1H)-Pyrimidinone, 4-amino-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:71-30-7 SDS

71-30-7Synthetic route

C-(6-Methoxy-2-p-tolyl-quinolin-4-yl)-N-(2-oxo-1,2-dihydro-pyrimidin-4-yl)-methanesulfonamide

C-(6-Methoxy-2-p-tolyl-quinolin-4-yl)-N-(2-oxo-1,2-dihydro-pyrimidin-4-yl)-methanesulfonamide

A

6-methoxy-2-(p-tolyl)quinoline
117839-37-9

6-methoxy-2-(p-tolyl)quinoline

B

Cytosine
71-30-7

Cytosine

C

6-methoxy-4-methyl-2-(p-tolyl)quinoline
117839-39-1

6-methoxy-4-methyl-2-(p-tolyl)quinoline

Conditions
ConditionsYield
In isopropyl alcohol Irradiation; 350 nm;A n/a
B 94%
C n/a
2-thiocytosine
333-49-3

2-thiocytosine

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With dihydrogen peroxide at 80℃; for 20h; Temperature;93%
3-hydroxylacrylic nitrile
25078-62-0

3-hydroxylacrylic nitrile

urea
57-13-6

urea

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
Stage #1: 3-hydroxylacrylic nitrile With sodium t-butanolate In tert-butyl alcohol
Stage #2: urea In tert-butyl alcohol at 50℃; for 8h; Solvent; Reagent/catalyst; Temperature;
91.5%
urea, monosodium salt
29878-39-5

urea, monosodium salt

3-hydroxylacrylic nitrile
25078-62-0

3-hydroxylacrylic nitrile

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
Stage #1: 3-hydroxylacrylic nitrile With sodium methylate In methanol
Stage #2: urea, monosodium salt In methanol at 40℃; for 6h;
91.5%
urea, monopotassium salt
89186-10-7

urea, monopotassium salt

3-hydroxylacrylic nitrile
25078-62-0

3-hydroxylacrylic nitrile

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
Stage #1: 3-hydroxylacrylic nitrile With sodium methylate In methanol
Stage #2: urea, monopotassium salt In methanol at 40℃; for 6h;
91.5%
4-amino-2-methoxypyrimidine
3289-47-2

4-amino-2-methoxypyrimidine

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With hydrogenchloride; water at 100℃; for 1h; Temperature;91.2%
With hydrogenchloride; water
4-amino-2-(methylthio)pyrimidine
2183-66-6

4-amino-2-(methylthio)pyrimidine

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With hydrogenchloride; water at 90℃; for 1h;90.9%
2-benzylsulfanyl-pyrimidin-4-ylamine
60722-70-5

2-benzylsulfanyl-pyrimidin-4-ylamine

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With hydrogenchloride; water at 90℃; for 1h;90.6%
2-ethylsulfanyl-pyrimidin-4-ylamine
54308-63-3

2-ethylsulfanyl-pyrimidin-4-ylamine

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With hydrogenchloride; water at 90℃; for 1h;89.7%
With ethanol; water; dihydrogen peroxide
3,3-diethoxypropenenitrile
35146-02-2

3,3-diethoxypropenenitrile

urea
57-13-6

urea

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With sodium hydroxide In toluene for 12h; Reflux;89%
5-carboxylcytosine
3650-93-9

5-carboxylcytosine

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With ammonium chloride In 1-methyl-pyrrolidin-2-one at 180℃; for 8h; Reagent/catalyst; Temperature; Solvent;87%
3-hydroxyacrylonitrile sodium salt
76064-23-8

3-hydroxyacrylonitrile sodium salt

urea
57-13-6

urea

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
In toluene for 5h;84%
N4-<(Dimethylamino)methylene>cytosine
76299-81-5

N4-<(Dimethylamino)methylene>cytosine

A

Cytosine
71-30-7

Cytosine

B

<(Dimethylamino)methylene>cyanamide
39687-97-3

<(Dimethylamino)methylene>cyanamide

Conditions
ConditionsYield
In isopropyl alcohol for 2h; Heating;A n/a
B 81%
N4-<(Dimethylamino)methylene>cytosine
76299-81-5

N4-<(Dimethylamino)methylene>cytosine

A

Cytosine
71-30-7

Cytosine

B

<(Dimethylamino)methylene>cyanamide
39687-97-3

<(Dimethylamino)methylene>cyanamide

Conditions
ConditionsYield
With sodium cyanamide In isopropyl alcohol for 2h; Heating;A n/a
B 81%
4-methylsulfanylpyrimidin-2(1H)-one
35551-31-6

4-methylsulfanylpyrimidin-2(1H)-one

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With ferrous(II) sulfate heptahydrate; ammonium hydroxide at 80℃; for 72h;77%
4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one
1257309-82-2

4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

A

N-(1,3-propanediol-2-yl)acetamide
2655-79-0

N-(1,3-propanediol-2-yl)acetamide

B

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With ammonium hydroxide; water In methanol at 70℃; for 24h; Sealed tube;A 71%
B 75%
C5H6N2O2

C5H6N2O2

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene at 120℃; under 11251.1 Torr; for 20h; Autoclave;74%
N4-<(Dimethylamino)methylene>cytosine
76299-81-5

N4-<(Dimethylamino)methylene>cytosine

A

Cytosine
71-30-7

Cytosine

B

N-[6-Oxo-6,7-dihydro-pyrimido[1,6-a][1,3,5]triazin-(4E)-ylidene]-guanidine; hydrochloride
76299-79-1

N-[6-Oxo-6,7-dihydro-pyrimido[1,6-a][1,3,5]triazin-(4E)-ylidene]-guanidine; hydrochloride

Conditions
ConditionsYield
With guanidine hydrochloride In isopropyl alcohol for 17h; Heating;A 67%
B 8%
2'-Deoxycytidine
951-77-9

2'-Deoxycytidine

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With purine nucleoside phosphorylase at 14 - 15℃; pH=7; aq. phosphate buffer; Enzymatic reaction;60%
4 % Chromat.
4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one
1257309-82-2

4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

A

N-(1,3-propanediol-2-yl)acetamide
2655-79-0

N-(1,3-propanediol-2-yl)acetamide

B

4-amino-1-{N-[1-hydroxy-3-(pivaloyloxymethyl)prop-2-yl]acetylaminomethyl}-1H-pyrimidin-2-one

4-amino-1-{N-[1-hydroxy-3-(pivaloyloxymethyl)prop-2-yl]acetylaminomethyl}-1H-pyrimidin-2-one

C

4-(amino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

4-(amino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

D

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With ammonium hydroxide; water In methanol at 20℃; for 24h;A 58%
B 4%
C 12%
D 60%
CYTIDINE
65-46-3

CYTIDINE

A

Cytosine
71-30-7

Cytosine

B

uracil
66-22-8

uracil

Conditions
ConditionsYield
With sodium persulfate In water at 75℃; for 4h; sodium phosphate buffer pH 7.0, other substrates;A 53%
B 6%
methanol
67-56-1

methanol

Flucytosine
2022-85-7

Flucytosine

A

5-methoxycytosine
31458-47-6

5-methoxycytosine

B

Cytosine
71-30-7

Cytosine

C

6-methoxycytosine

6-methoxycytosine

Conditions
ConditionsYield
for 3h; Mechanism; Product distribution; Irradiation; other alcohol;A 36%
B 9%
C 31%
for 3h; Irradiation;A 36%
B 9%
C 31%
1-(2-C-cyano-2-deoxy-β-D-arabinofuranosyl)cytosine hydrochloride
134665-72-8

1-(2-C-cyano-2-deoxy-β-D-arabinofuranosyl)cytosine hydrochloride

A

Cytosine
71-30-7

Cytosine

B

1,4-anhydro-2-C-cyano-2-deoxy-D-erythropent-1-enitol

1,4-anhydro-2-C-cyano-2-deoxy-D-erythropent-1-enitol

C

2'-C-cyano-2'-deoxy-1-β-D-ribo-pentofuranosylcytosine

2'-C-cyano-2'-deoxy-1-β-D-ribo-pentofuranosylcytosine

Conditions
ConditionsYield
With Tris-HCl buffer at 37℃; for 6h; Rate constant; Mechanism; var. salt concentration and pH of buffer;A n/a
B 28%
C 33%
α-cytidine-5′-phosphate

α-cytidine-5′-phosphate

A

Cytosine
71-30-7

Cytosine

B

C9H12N3O7P(2-)

C9H12N3O7P(2-)

C

C9H11N2O8P(2-)

C9H11N2O8P(2-)

D

C6H8NO7P(2-)

C6H8NO7P(2-)

E

C9H12N3O7P(2-)

C9H12N3O7P(2-)

F

C9H11N2O8P(2-)

C9H11N2O8P(2-)

G

uracil
66-22-8

uracil

H

C9H11N2O8P(2-)

C9H11N2O8P(2-)

Conditions
ConditionsYield
In water at 90℃; for 16h; pH=6.5; Irradiation; Inert atmosphere;A 12%
B 5%
C 11%
D 22%
E 5%
F 9%
G 14%
H 5%
2-chloropyrimidin-4-amine
7461-50-9

2-chloropyrimidin-4-amine

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With hydrogenchloride; water
4-ethoxypyrimidin-2-one
6220-43-5

4-ethoxypyrimidin-2-one

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With ethanol; ammonia at 120℃;
(4-amino-pyrimidin-2-ylsulfanyl)-acetic acid
61445-73-6

(4-amino-pyrimidin-2-ylsulfanyl)-acetic acid

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With hydrogenchloride; water
cytidinium sulphate
32747-18-5

cytidinium sulphate

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With sulfuric acid at 125℃; im Rohr;
3-ethoxyacrylonitrile
61310-53-0

3-ethoxyacrylonitrile

urea
57-13-6

urea

Cytosine
71-30-7

Cytosine

Conditions
ConditionsYield
With sodium butanolate
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Cytosine
71-30-7

Cytosine

C19H29N3O7
1108637-27-9

C19H29N3O7

Conditions
ConditionsYield
With dmap In tetrahydrofuran at 70℃; for 0.116667h; Microwave irradiation; Green chemistry;100%
With dmap In tetrahydrofuran at 20℃; for 12h; Inert atmosphere;91%
With dmap In tetrahydrofuran
Cytosine
71-30-7

Cytosine

C26H33FO6Si

C26H33FO6Si

C28H34FN3O5Si

C28H34FN3O5Si

Conditions
ConditionsYield
Stage #1: Cytosine With N,O-bis-(trimethylsilyl)-acetamide In 1,2-dichloro-ethane at 20℃; for 2h; Reflux;
Stage #2: C26H33FO6Si With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; for 2h; Reflux;
100%
Cytosine
71-30-7

Cytosine

5-iodocytosine
1122-44-7

5-iodocytosine

Conditions
ConditionsYield
With N-iodo-succinimide In N,N-dimethyl-formamide for 12.5h; Sonographic reaction; Inert atmosphere;99%
With iodine; iodic acid In acetic acid at 40℃;96%
With iodine; iodic acid; acetic acid In tetrachloromethane; water at 50℃;86%
N,N-dimethylformamide dipropyl acetal
6006-65-1

N,N-dimethylformamide dipropyl acetal

Cytosine
71-30-7

Cytosine

N4-<(Dimethylamino)methylene>-1-propylcytosine
79044-11-4

N4-<(Dimethylamino)methylene>-1-propylcytosine

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 24h; Heating;99%
Cytosine
71-30-7

Cytosine

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

N4-<(Dimethylamino)methylene>-1-methylcytosine
77738-01-3

N4-<(Dimethylamino)methylene>-1-methylcytosine

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 24h; Heating; other N,N-dimethylformamide dialkyl(diaralkyl) acetales;99%
In N,N-dimethyl-formamide for 24h; Heating;99%
trifluoroacetic acid for 15h; Heating;98%
With trifluoroacetic acid
Cytosine
71-30-7

Cytosine

N,N-dimethylformamide diethyl diacetal
1188-33-6

N,N-dimethylformamide diethyl diacetal

N4-<(Dimethylamino)methylene>-1-ethylcytosine
79044-10-3

N4-<(Dimethylamino)methylene>-1-ethylcytosine

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 24h; Heating;99%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Cytosine
71-30-7

Cytosine

tert-butyl 4-[bis(tert-butoxycarbonyl)amino]-2-oxopyrimidine-1(2H)-carboxylate

tert-butyl 4-[bis(tert-butoxycarbonyl)amino]-2-oxopyrimidine-1(2H)-carboxylate

Conditions
ConditionsYield
With dmap In tetrahydrofuran at 20℃; Inert atmosphere;99%
Cytosine
71-30-7

Cytosine

(propa-1,2-dien-1-yloxy)cyclohexane

(propa-1,2-dien-1-yloxy)cyclohexane

(S)-4-amino-1-(1-(cyclohexyloxy)allyl)pyrimidin-2(1H)-one

(S)-4-amino-1-(1-(cyclohexyloxy)allyl)pyrimidin-2(1H)-one

Conditions
ConditionsYield
With pyridine; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane at 20℃; for 24h; Inert atmosphere; enantioselective reaction;98.5%
Cytosine
71-30-7

Cytosine

acetic anhydride
108-24-7

acetic anhydride

4-N-Acetylcytosine
14631-20-0

4-N-Acetylcytosine

Conditions
ConditionsYield
With phosphoric acid at 100℃; for 8h;98%
With pyridine for 2.5h; Heating;97.2%
With pyridine at 20℃; for 24h;85%
N,N-dimethylformamide dipropyl acetal
6006-65-1

N,N-dimethylformamide dipropyl acetal

Cytosine
71-30-7

Cytosine

N4-<(Dimethylamino)methylene>cytosine
76299-81-5

N4-<(Dimethylamino)methylene>cytosine

Conditions
ConditionsYield
With trifluoroacetic acid at 85 - 90℃; for 12h;98%
N,N-dimethylformamide di-n-butyl acetal
18503-90-7

N,N-dimethylformamide di-n-butyl acetal

Cytosine
71-30-7

Cytosine

1-Butyl-N4-<(dimethylamino)methylene>cytosine
79044-12-5

1-Butyl-N4-<(dimethylamino)methylene>cytosine

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 24h; Heating;98%
Cytosine
71-30-7

Cytosine

2-Methylpropionic anhydride
97-72-3

2-Methylpropionic anhydride

N6-isobutyrylaminocytosine
97626-98-7

N6-isobutyrylaminocytosine

Conditions
ConditionsYield
With pyridine for 2h; Heating;98%
In N,N-dimethyl-formamide Heating;80%
Cytosine
71-30-7

Cytosine

dibutylformamide dineopentyl acetal

dibutylformamide dineopentyl acetal

N,N-Dibutyl-N'-(2-oxo-1,2-dihydro-pyrimidin-4-yl)-formamidine

N,N-Dibutyl-N'-(2-oxo-1,2-dihydro-pyrimidin-4-yl)-formamidine

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 2h; Ambient temperature;98%
Cytosine
71-30-7

Cytosine

2-Chloro-N-[2-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-acetamide
406215-03-0

2-Chloro-N-[2-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-acetamide

2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-N-[2-(3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-acetamide
406215-10-9

2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-N-[2-(3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-acetamide

Conditions
ConditionsYield
Stage #1: Cytosine With sodium hydride; triethylamine In N,N-dimethyl-formamide for 0.0833333h;
Stage #2: 2-Chloro-N-[2-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl]-acetamide In N,N-dimethyl-formamide at 20℃; Further stages.;
98%
Cytosine
71-30-7

Cytosine

4‐amino‐[5,6‐D2]pyrimidin‐2(1H)‐one deuterium chloride

4‐amino‐[5,6‐D2]pyrimidin‐2(1H)‐one deuterium chloride

Conditions
ConditionsYield
Stage #1: Cytosine With platinum(IV) oxide; sodium tetrahydroborate; palladium on activated charcoal; water-d2 at 160℃; for 1.33333h; Microwave irradiation;
Stage #2: With hydrogen chloride at 0℃;
98%
silver hexafluoroantimonate

silver hexafluoroantimonate

chloromethyl(1,5-cyclooctadiene)platinum(II)

chloromethyl(1,5-cyclooctadiene)platinum(II)

Cytosine
71-30-7

Cytosine

[(1,5-cyclooctadiene)PtMe(cytosine)](SbF6)
921800-07-9, 921800-01-3, 1160938-96-4

[(1,5-cyclooctadiene)PtMe(cytosine)](SbF6)

Conditions
ConditionsYield
In acetone (Ar); Ag salt was added to stirred soln. of Pt in acetone; stirred for 30 min; filtered; suspn. of cytosine in acetone was added; stirred for 30min; solvent removed; washed (H2O); dried (vac.); elem. anal.;97.5%
Cytosine
71-30-7

Cytosine

C4(2)H5N3O

C4(2)H5N3O

Conditions
ConditionsYield
Stage #1: Cytosine With molybdenum(IV) oxide; sodium tetrahydroborate; palladium 10% on activated carbon; water-d2 at 20 - 160℃; for 1.83333h; Microwave irradiation;
Stage #2: With hydrogen chloride In water for 0.333333h;
97.5%
Cytosine
71-30-7

Cytosine

N4-sulfamoylcytosine

N4-sulfamoylcytosine

Conditions
ConditionsYield
With pyridine; sulfamate de pentachlorophenyle at 100℃; for 2h; regioselective transfer of the sulfamoyl group to the extracyclic NH2 group of amniopyrimidines and amonopurines;97%
With pyridine; sulfamate de pentachlorophenyle at 100℃; for 2h;97%
N,N-Dimethylformamide diallyl acetal
61296-25-1

N,N-Dimethylformamide diallyl acetal

Cytosine
71-30-7

Cytosine

1-Allyl-N4-<(dimethylamino)methylene>cytosine
79044-13-6

1-Allyl-N4-<(dimethylamino)methylene>cytosine

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 24h; Heating;96%
Cytosine
71-30-7

Cytosine

water
7732-18-5

water

barium(II) perchlorate

barium(II) perchlorate

{[Ba(cytosine)2(H2O)](ClO4)2}n

{[Ba(cytosine)2(H2O)](ClO4)2}n

Conditions
ConditionsYield
Stage #1: Cytosine; water at 45℃; for 0.5h;
Stage #2: barium(II) perchlorate at 20℃;
96%
Cytosine
71-30-7

Cytosine

Flucytosine
2022-85-7

Flucytosine

Conditions
ConditionsYield
Stage #1: Cytosine With hydrogen fluoride at -15 - 0℃; Inert atmosphere;
Stage #2: at -20℃; for 4h; Inert atmosphere; Further stages;
95.7%
With 1,1,1,3',3',3'-hexafluoro-propanol; fluorine at 20℃; under 1125.11 Torr; Temperature; Pressure; Reagent/catalyst; Inert atmosphere;87.4%
With formic acid for 1.5h; Time; Flow reactor; Autoclave;63%
With formic acid; fluorine at 9℃; for 0.0833333h; Temperature; Concentration; Inert atmosphere;
Cytosine
71-30-7

Cytosine

5-bromocytosine
2240-25-7

5-bromocytosine

Conditions
ConditionsYield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 15℃; for 1h; Reagent/catalyst; Solvent; Sonication;95.6%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 25℃; for 10h; Large scale;93.6%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 25℃; for 10h;93.6%
Cytosine
71-30-7

Cytosine

4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

N4-(4-methoxybenzoyl)-cytosine
51820-70-3

N4-(4-methoxybenzoyl)-cytosine

Conditions
ConditionsYield
With pyridine at 20℃;95%
With pyridine at 80℃; for 2h; Acylation;93%
With pyridine at 80℃; for 2h;81%
With pyridine; dmap In dichloromethane at 20℃; Inert atmosphere;
Cytosine
71-30-7

Cytosine

tert-butyl (2R,3S,5R)-2-(acetyloxy)-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate
496848-33-0

tert-butyl (2R,3S,5R)-2-(acetyloxy)-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate

tert-butyl (2RS,3S,5R)-2-[4-amino-2-oxopyrimidin-1(2H)-yl]-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate
496848-38-5

tert-butyl (2RS,3S,5R)-2-[4-amino-2-oxopyrimidin-1(2H)-yl]-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: Cytosine; tert-butyl (2R,3S,5R)-2-(acetyloxy)-5-[(tert-butyldimethylsilyloxy)methyl]-3-(trifluoromethyl)pyrrolidine-1-carboxylate With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile for 0.5h; Heating;
Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 20℃; for 16h;
95%
bis(η3-allyl-μ-chloropalladium(II))

bis(η3-allyl-μ-chloropalladium(II))

Cytosine
71-30-7

Cytosine

η3-allylchloro(cytosine)palladium(II)
96226-53-8

η3-allylchloro(cytosine)palladium(II)

Conditions
ConditionsYield
In methanol soln. stirred for 3h, pptn (molar ratio complex : ligand = 1:2); filtered, washed (MeOH, ether), dried (vac.), elem. anal.;95%
N-chloro-succinimide
128-09-6

N-chloro-succinimide

Cytosine
71-30-7

Cytosine

5-chloro-cytosine
2347-43-5

5-chloro-cytosine

Conditions
ConditionsYield
With acetic acid at 70 - 77℃; for 4.3h;95%
(3R,4S,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-5-vinyltetrahydrofuran-2,3-diyl diacetate
1146197-36-5

(3R,4S,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-5-vinyltetrahydrofuran-2,3-diyl diacetate

Cytosine
71-30-7

Cytosine

(2R,3R,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-(benzyloxy)-5-(benzyloxymethyl)-5-vinyltetrahydrofuran-3-yl acetate

(2R,3R,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-(benzyloxy)-5-(benzyloxymethyl)-5-vinyltetrahydrofuran-3-yl acetate

Conditions
ConditionsYield
Stage #1: Cytosine In acetonitrile at 20℃; for 3h; Vorbrueggen Nucleoside Synthesis;
Stage #2: (3R,4S,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-5-vinyltetrahydrofuran-2,3-diyl diacetate With tin(IV) chloride In acetonitrile at 65℃; for 1h;
95%
Cytosine
71-30-7

Cytosine

α-D-erythropentafuranose-2'-deoxy-2',2'-difluoro-3,5-dibenzoate-1-methanesulfonate
134877-43-3

α-D-erythropentafuranose-2'-deoxy-2',2'-difluoro-3,5-dibenzoate-1-methanesulfonate

β-1-(2’-deoxy-2’,2’-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

β-1-(2’-deoxy-2’,2’-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

Conditions
ConditionsYield
Stage #1: Cytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane Reflux; Industrial scale;
Stage #2: α-D-erythropentafuranose-2'-deoxy-2',2'-difluoro-3,5-dibenzoate-1-methanesulfonate With hydrogenchloride; phosphomolybdic acid In pentan-1-ol at 128 - 137℃; for 5h; Temperature; Solvent; Industrial scale;
95%
Stage #1: Cytosine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 3h; Reflux;
Stage #2: α-D-erythropentafuranose-2'-deoxy-2',2'-difluoro-3,5-dibenzoate-1-methanesulfonate With phosphotungstic acid In i-Amyl alcohol at 64℃; Reagent/catalyst; Temperature; Solvent; Time; Further stages;
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Cytosine
71-30-7

Cytosine

[Ru(η6-p-cymene)(cytosine-κN4)Cl2]

[Ru(η6-p-cymene)(cytosine-κN4)Cl2]

Conditions
ConditionsYield
In methanol for 4h; Inert atmosphere;95%
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

Cytosine
71-30-7

Cytosine

(2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 9H-fluoren-9-ylmethyl ester

(2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 100℃; for 2h;95%

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields