Highly diastereoselective addition of cyanide to β-hydroxyketones

DOI: 10.1016/S0040-4039(00)92403-1

Source and publish data:

Tetrahedron Letters p. 5423 - 5424 (1991)

Update date:2022-07-30

Topics:

Authors:

Brunet Brunet

Singh Batra

Aguilar Aguilar

Garcia Ruano

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Article abstract of DOI:10.1016/S0040-4039(00)92403-1

The addition of cyanide with KCN/ZnI₂/TMSCN to β-hydroxyketones (R₁-CHOH-CO-R₂, R₁ = i-Pr, R₂ = Me, Et, i-Bu, i-Pr, t-Bu, R₁ = Et, R₂ = t-Bu and R₁ = Bn, Ph, R₂ = i-Bu) produced syn β-hydroxycyanohydrins in 95% d.e.

Full text of DOI:10.1016/S0040-4039(00)92403-1

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