Turkish Journal of Chemistry p. 279 - 291 (2012)
Update date:2022-07-30
Topics:
Guelkok, Yildiz
Bicer, Tuba
Onurdag, Fatma Kaynak
Oezgen, Selda
Sahin, Mustafa Fethi
Dogruer, Deniz Songuel
In the present study, 18 new compounds were synthesized, 9 of which were urea (9a-e, 10a-d) while the others were thiourea (11a-e, 12a-d) derivatives. These derivatives were prepared by the reaction of 6-amino-5-nonsubstituted/ chloro-3-methyl-2(3H) -benzoxazolones used as key intermediates with the appropriate isocyanates and isothiocyanates. The chemical structures of new compounds were confirmed by 1H-NMR, mass, and elemental analysis. The synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains. Compounds 9a, 9b, 9e, 10a, and 10c, urea derivatives, and compounds 12a and 12d, thiourea derivatives, exhibited a relatively good inhibitory profile against E. coli, with a MIC value of 32 ig/mL when compared with the other target compounds.
View MoreEASYBUYER Co.,LTD.( Chen-Chen )
Contact:+86-21-51816013/51816067
Address:1306,Bldg 8 Hi-Shanghai Center,No.950 Dalian Rd
Beijing Wisdom Chemicals Co., Ltd.
Contact:+86-10-52350335
Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Shanxi Tongji Pharmaceuticals Co., Ltd.
Contact:+86-359-3024784
Address:Xikuang South Road, Ruicheng County , Shanxi
KINHENG CHEMICAL(SHANGHAI)CO., LTD.
Contact:+8621-60490170
Address:Room401, No.28,Lane 189, Yangshupu Rd. Shanghai, China.
Changsha Huajing Powdery Material Technological Co., Ltd.
Contact:86-731-88879686
Address:Building 2, West Garden, Main Campus of Central South University, Changsha, Hunan Province, China
Doi:10.1016/S0957-4166(00)86152-2
(1991)Doi:10.1039/c4ob01400f
(2014)Doi:10.1016/j.bmc.2012.05.064
(2012)Doi:10.1016/0040-4039(91)80455-F
(1991)Doi:10.1016/j.tetlet.2012.05.098
(2012)Doi:10.1002/jhet.5570280702
(1991)