Developing a novel dual PI3K-mTOR inhibitor from the prodrug of a metabolite

DOI: 10.2147/OTT.S142492

Source and publish data:

OncoTargets and Therapy p. 5077 - 5087 (2017)

Update date:2022-09-26

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Authors:

Zhou, Yan

Zhang, Genyan

Wang, Feng

Wang, Jin

Ding, Yanwei

Li, Xinyu

Shi, Chongtie

Li, Jiakui

Shih, Chengkon

You, Song

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Article abstract of DOI:10.2147/OTT.S142492

This study presents a process of developing a novel PI3K-mTOR inhibitor through the prodrug of a metabolite. The lead compound (compound 1) was identified with similar efficacy as that of NVP-BEZ235 in a tumor xenograft model, but the exposure of compound

Full text of DOI:10.2147/OTT.S142492

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