A Stereocontrolled Synthesis of a C19-C32/C17-C30 Segment for Swinholide A and Misakinolide A, Cytotoxic Dimeric Macrolides from Theonella Swinhoei.

DOI: 10.1016/S0040-4039(00)78876-9

Source and publish data:

Tetrahedron Letters p. 2847 - 2850 (1992)

Update date:2022-07-29

Topics:

Authors:

Paterson, Ian

Cumming, John G.

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Article abstract of DOI:10.1016/S0040-4039(00)78876-9

The C19-C32/C17-C30 segment (-)-5 of swinholide A/misakinolide A was prepared in 15 steps (6percent yield) from (+/-)-13.Key steps include the Sharpless epoxidation, 13 -> 14, the acetal allylation, 12 -> 16, the anti aldol, 17 + 11 -> 9, and the alkene h

Full text of DOI:10.1016/S0040-4039(00)78876-9

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