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Best price Progesterone Fast Delivery and Manufacturer
Cas No: 57-83-0
No Data 1 Kilogram 3 Metric Ton/Month Hubei Danao Pharmaceutical Co.,Ltd. Contact Supplier
Progesterone 99%
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USD $ 50.0-50.0 / Kilogram 1 Kilogram 1000 Kilogram/Week Antimex Chemical Limied Contact Supplier
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No Data 1 Kilogram 5 Metric Ton/Month Shaanxi WuZhiYuan Biological Technology Co.,Ltd Contact Supplier
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No Data 100 Gram 1-100 Metric Ton/Month Wuhan Zenuo Biological Medicine Technology Co Ltd Contact Supplier
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No Data 25 Kilogram Metric Ton/Day HANGZHOU CLAKE BIOTECH CO.,LTD Contact Supplier
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USD $ 0.7-1.0 / Gram 10 Gram 1000 Kilogram/Year Wuhan Jing Chu Chen Pharmaceutical Chemical Co., Ltd. Contact Supplier
High purity Progesterone 99% lower price
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USD $ 2500.0-2500.0 / Kilogram 1 Kilogram 1000 Kilogram/Year Shanghai Upbio Tech Co.,Ltd Contact Supplier
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No Data 1 Gram 500 Kilogram/Month Beijing Mesochem Technology Co.,LTD Contact Supplier
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No Data 100 Gram 100 Metric Ton/Month Senova Technology Company Limited Contact Supplier

57-83-0 Usage

Description

Progesterone is a hormone released by luteal cells in the ovaries which contains 21 Carbon Atoms. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids. There are two crystal forms of progesterone, that are type-α and type-β, the two types have similar physiological activity. Type-α is precipitated from dilute ethanol as orthorhombic white prismatic crystal, while type-β is orthorhombic white needle crystal, they are both insoluble in water, but soluble in ethanol, ethyl ether, chloroform, acetone, dioxane and concentrated sulfuric acid.
Progesterone can be released by the ovary, placenta and adrenal cortex. Its physiological function mainly manifests in promoting estrogen treated over thicken lining of the uterus to continue the development, proliferation and thickening and hypertrophy, soften and secretion of mucus in order to make good condition for implantation of the fertilized egg. After the implantation, early stage survival and development of fertilized egg is also under the control of the high progesterone release. As a result, progesterone is a very important hormone in the female reproductive system, and it is also an important intermediate in the biosynthesis of steroid hormones. All steroid hormone releasable glands can produce progesterone, but only ovarian and placenta can release progesterone as the main hormone. Ovarian will release large amount of progesterone in the luteal phase after ovulation by granulose luteal cells, so progesterone is also named as progestin. Progesterone will decrease in result of corpus luteum atrophy. For normal women, placenta will becomes the main organ maintain progesterone after 8 to 9 weeks of pregnancy, accompany with the ovary releasing until the end of pregnancy.

Chemical Properties

White powder. Melting point 121°C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.

Brand name

Crinone (Columbia); Prometrium (Unimed).

Purification Methods

The form crystallises from EtOH with m 127-131o. The -form crystallises from pet ether or aqueous pet ether/aqueous Et2O with m 119-120o or 121o. It also crystallises from Et2O, Me2CO/EtOAc, MeOH, aqueous Et2O, aqueous MeOH, wet pet ether, Et2O/pet ether, pet ether/*C6H6, Et2O/pentane and isopropyl ether. The is at 240nm with log 4.25 (EtOH). [Wintersteiner & Allen J Biol Chem 107 max 321 1934, Beilstein 7 III 3648, 7 IV 2395.]

Uses

The main physiological effects of progesterone:
1. Progesterone can maintain the female animal pregnancy, and cause a series of physiological changes, such as inhibition of female estrus.
2. Progesterone has the power to promote the thickening of the lining of the uterus, promote the bending of the gland and to increase secretion function.
3. Progesterone can inhibit the peristalsis of the uterus, and contribute to the cervix contraction, secretion of mucus, etc.. These physiological changes provide suitable environment for the operation, growth and development of early embryos, as well as the continued growth of the fetus.
4. Small amount of progesterone is also used in combination with the hormone estrogen to promote female estrus. The synergy between progesterone and prolactin can promote the development of mammary glands.
5. Progesterone is involved in the feedback regulation of the hypothalamus and anterior pituitary, which makes the balance of the animal reproductive hormones. In vivo, progesterone content of all sorts of livestock follicular phase is below 1 ng/ml, while in bovine corpus luteum period is approximately 4 ng/ml, pregnancy period is about 18 ng/ml.
6. Formerly biochemical study shows that progesterone modulates action as progestogens, clinical for the treatment of habitual abortion, dysmenorrhea, amenorrhea and other symptoms. One of progesterone's most important functions is as hormone drugs, to promote and maintain the uterine changes in the early stage of pregnancy, used in habitual abortion, irregular menstruation, etc.. In addition, progesterone also behaves as steroid hormone drug as well as progestogens, which is used in treatment of threatened abortion.

Air & Water Reactions

Insoluble in water.

Biological Activity

Endogenous progesterone receptor (PR) agonist (EC 50 = 0.5 nM).

Uses

Sterid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer

Definition

ChEBI: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and ot er species.

Fire Hazard

Flash point data for Progesterone are not available; however, Progesterone is probably combustible.

Preparation

Progesterone can be obtained by oxidation of the pregnenolone. Dry toluene was added to a oven dried reaction kettle, and then cyclohexanone and pregnenolone were added in order with vigorous stirring to dissolve. Side product H2O was removed by Soxhlet extraction with toluene steam, aluminium isopropoxidequickly was added flowingly, the oxidation reaction was hold on at 115 oC for 2h, cooling to 80 oC, add 5% dilute sulfuric acid under stirring then stand by until water and toluene separated, the toluene layer was extracted with water to neutrality and then distillation off toluene and cyclohexanone. Cooling, filtering, filter cake was beated with petroleum, filtering, washing with petroleum, dried as crude progesterone. The crude product was dissolved in ethanol, decolorized by activated carbon, recrystallized to get the final product, yield 80%. Another way to produce progesterone is choosing the 16-Dehydropregnenolone acetate as start material, treated consecutively by catalytic hydrogenation, alkali hydrolysis, oxidation by aluminum isopropoxide, to get the progesterone as final product.

Reactivity Profile

Progesterone is sensitive to light .

Health Hazard

ACUTE/CHRONIC HAZARDS: Progesterone may be absorbed through the skin.
InChI:InChI=1/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1

57-83-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (P0130)  Progesterone  ≥99% 57-83-0 P0130-100G 5,499.00CNY Detail
Sigma (P0130)  Progesterone  ≥99% 57-83-0 P0130-25G 1,535.04CNY Detail
Sigma-Aldrich (Y0001665)  Progesterone for system suitability  European Pharmacopoeia (EP) Reference Standard 57-83-0 Y0001665 1,880.19CNY Detail
Sigma-Aldrich (Y0001666)  Progesterone for peak identification  European Pharmacopoeia (EP) Reference Standard 57-83-0 Y0001666 1,880.19CNY Detail
TCI America (P0478)  Progesterone  >98.0%(HPLC) 57-83-0 25g 450.00CNY Detail
TCI America (P0478)  Progesterone  >98.0%(HPLC) 57-83-0 5g 185.00CNY Detail

57-83-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name progesterone

1.2 Other means of identification

Product number -
Other names Luteol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Veterinary Drug: PRODUCTION_AID
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57-83-0 SDS

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