Chemical and Pharmaceutical Bulletin p. 1808 - 1813 (1992)
Update date:2022-08-02
Topics:
Imaizumi
Kano
Sakata
A series of 1-amino-5-substituted uracils and their 4-thio or 2,4-dithio substituted analogues were synthesized and assayed for anti-conflict activity in rats and anesthetic activity in mice. 1-Amino-5-halogenouracils 3b-e, 1-amino-4-thiouracil (9a), and 1-amino-5-halogeno-4-thiouracils 9c, d showed both anti-conflict and anesthetic activities. The most active compound was 1-amino-5-chloro-4-thiouracil (9d) which showed anxiolytic activity at 2 mg/kg of oral administration (p.o.) on a modified Geller-Seifter conflict schedule. Its minimum effective dose (MED) was lower than that of diazepam. The 50 percent effective dose (ED50) for anesthetic activity in mice of the compound (9d) was 32.9 mg/kg, p.o.
View MoreLIAONING DMSO CHEMICALS CO.,LTD.
website:http://www.chinadmso.com
Contact:+86-427-6503033
Address:FLOOR 16, BLOCK A, FINANCIAL SQUARE, XINGLONGTAI DISTRICT, PANJIN CITY, LIAONING P.R. CHINA
Chongqing KonAo Health Co.,Ltd
Contact:13687578375
Address:wuhan hubei china
Disynthesis Chemical Technology Co. Ltd.
Contact:+86-571-88194596
Address:Dengyun road 380, Gongshu district, Hangzhou city, China
Yicheng Goto Pharmaceuticals Co.,Ltd.
Contact:+86 710 3423122
Address:5th Floor,East Gate of Building #2,Servo-Industrial Park,1st Qilin Road,Xiangyang,Hubei,China
Cangzhou Bao Lai Da Import&Export Trading Co.,Ltd
Contact:86-317-2096605
Address:Cangzhou City,HeBei Province,China
Doi:10.1016/j.tetlet.2013.01.032
(2013)Doi:10.1021/jo00041a052
(1992)Doi:10.1021/jm950625l
(1996)Doi:10.1016/j.tet.2013.01.042
(2013)Doi:10.1021/ol400401d
(2013)Doi:10.1016/j.jfluchem.2013.01.012
(2013)
