Convergent synthesis of the streptonigrin alkaloid skeleton. Directed orthometalation connection to aryl-aryl cross-coupling

Article abstract of DOI:10.1016/S0040-4020(01)92191-X

A convergent synthesis of 2-[2-(4-phenyl-3-pivaloylamino) pyridyl]quinolines, the streptonigrin alkaloid skeleton, is reported. The methodology involves independent elaboration of the three main building blocks by metalation and two coupling reactions cat