Reaction of Dianions of Acyclic β-Enamino Ketones with Electrophiles. 3. Nitriles: Synthesis of Pyridine and Pyrimidine Derivatives

Article abstract of DOI:10.1021/jo00048a043

A new method for the construction of pyridine and pyrimidine derivatives is described, based on the electrophilic attack of nitriles to dianions of β-(monoalkylamino)-α,β-unsaturated ketones and the subsequent cyclization of the addition product.The react