Journal of Organic Chemistry p. 6579 - 6587 (1992)
Update date:2022-07-30
Topics:
Tottie, Louise
Baeckstroem, Peter
Moberg, Christina
Tegenfeldt, Joergen
Heumann, Andreas
Molecular sieves have been shown to improve greatly the stereoselectivity in the palladium(II)-catalyzed reaction of cis-1,2-divinylcyclohexane with chiral acids.Reactions run with molecular sieves and derivatives of (R)-lactic acids as nucleophiles always yielded products with S configuration at the newly formed chiral center in contrast to reactions without molecular sieves that gave products with either S or R configuration at this chiral center.It appears that this effect has not been observed previously.Only water-containing molecular sieves increased the stereoselectivity.A chiral palladium complex was formed faster in the presence of molecular sieves, but use of this complex as catalyst in the cyclization did not result in increased selectivity.The best stereoselectivity was found for molecular sieves with a high sodium content (Lancaster 13X and 4-Angstroem sieves).
View MoreZhangjiagang Golden Reach Fine Chemical Co.,LTD.
Contact:+86-512-6585 6968
Address:Changfu Road, Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Alchemist-pharm chemical Technology Co. Ltd.
website:http://www.alchemist-pharm.com
Contact:0086-371-67991738
Address:Address:No. 35 Dongqing Street High-tech District 450001, Zhengzhou China
website:http://www.cartoonchem.com/
Contact:+86-25-58074918
Address:Room 2109, RuiHua Business Center,315 South ZhongShan Road, Nanjing 210001, China
NINGBO PANGS CHEM INT’L CO.,LTD.
Contact:+86-574-27666845
Address:FLOOR 21,BUILDING NO.11,XIN TIAN DI,NO.689 SHI JI ROAD,NINGBO CHINA
website:http://www.sagechem.com
Contact:+86-571-86818502
Address:Room C1301, New Youth Plaza, 8 Jia Shan Road, Hangzhou, China
Doi:10.1016/j.bmcl.2013.05.016
(2013)Doi:10.1021/jacs.7b10586
(2017)Doi:10.1055/s-1992-26224
(1992)Doi:10.1016/j.ijantimicag.2013.03.007
(2013)Doi:10.1002/cctc.201300189
(2013)Doi:10.1021/jm400146r
(2013)