Synthesis of 3-(thiazol-4-yl)alanine and 3-(selenazol-4-yl)alanine derivatives from aspartic acid

DOI: 10.1055/s-1992-26323

Source and publish data:

Synthesis p. 1145 - 1150 (1992)

Update date:2022-08-05

Topics:

Authors:

Burger Burger

Gold Gold

Neuhauser

Rudolph Rudolph

Hoss Hoss

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Article abstract of DOI:10.1055/s-1992-26323

3-(Thiazol-4-yl)alanine as well as 3-(selenazol-4-yl)alanine and their derivatives can be obtained from aspartic acid, using hexafluoroacetone as protective group, via 2,2-bis(trifluoromethyl)-4-(3-bromo-2-oxopropyl)-1,3-oxazolidin-5-one (3) in a Hantzsch synthesis.

Full text of DOI:10.1055/s-1992-26323

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Product name:(S)-4-{2-[3-(2,6-Dimethyl-phenyl)-2-furan-2-yl-5-trifluoromethyl-3H-imidazol-4-yl]-thiazol-4-ylmethyl}-2,2-bis-trifluoromethyl-oxazolidin-5-one

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