Synthesis of 3-(thiazol-4-yl)alanine and 3-(selenazol-4-yl)alanine derivatives from aspartic acid

Article abstract of DOI:10.1055/s-1992-26323

3-(Thiazol-4-yl)alanine as well as 3-(selenazol-4-yl)alanine and their derivatives can be obtained from aspartic acid, using hexafluoroacetone as protective group, via 2,2-bis(trifluoromethyl)-4-(3-bromo-2-oxopropyl)-1,3-oxazolidin-5-one (3) in a Hantzsch synthesis.