Asymmetric synthesis of camptothecin alkaloids: A nine-step synthesis of (S)-camptothecin

DOI: 10.1016/S0040-4039(00)73492-7

Source and publish data:

Tetrahedron Letters p. 5331 - 5334 (1994)

Update date:2022-08-04

Topics:

Authors:

Comins, Daniel L.

Hong, Hao

Jianhua, Gao

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Article abstract of DOI:10.1016/S0040-4039(00)73492-7

DE Ring camptothecin intermediate II was prepared enantioselectively from 2-chloro-6 hydroxypyridine in six steps and used in a nine-step synthesis of (S)-camptothecin.

Full text of DOI:10.1016/S0040-4039(00)73492-7

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Product name:4(S)-4-ethyl-4-hydroxy-6-chloro-4,7-dihydro-1H-pyrano[3,4-c]pyridin-3,8-dione

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