Synthetic Studies on Duocarmycin. 2. Synthesis and Cytotoxicity of Natural (+)-Duocarmycin A and Its Tree Possible Stereoisomers.

Article abstract of DOI:10.1016/S0040-4020(01)86994-5

The title synthesis was achieved by featuring the optical resolution of two types of the tricyclic intermediates and the synthetic scheme established in the synthesis of racemic compounds.In vitro cytotoxicity assay against P388 murine leukemia obviously