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99-92-3

Basic Information
CAS No.: 99-92-3
Name: Ethanone,1-(4-aminophenyl)-
Molecular Structure:
Molecular Structure of 99-92-3 (Ethanone,1-(4-aminophenyl)-)
Formula: C8H9NO
Molecular Weight: 135.17
Synonyms: Acetophenone,4'-amino- (8CI);Acetophenone, p-amino- (3CI);1-(4-Aminophenyl)ethanone;1-Acetyl-4-aminobenzene;4-Acetylaniline;4-Acetylphenylamine;4-Aminophenylmethyl ketone;NSC 3242;p-Acetylaniline;p-Acetylphenylamine;p-Aminoacetophenone;p-Aminoacetylbenzene;p-Aminophenylmethyl ketone;4-Aminoacetophenone;
EINECS: 202-801-2
Density: 1.096 g/cm3
Melting Point: 103-107 °C(lit.)
Boiling Point: 294.8 °C at 760 mmHg
Flash Point: 132.1 °C
Solubility: It is soluble in hot water, ethanol and ether.
Appearance: slightly yellow to brown crystalline powder
Hazard Symbols: HarmfulXn,IrritantXi
Risk Codes: 22-36/37/38-20/21/22
Safety: 26-36
Transport Information:
PSA: 43.09000
LogP: 2.05260
Synthetic route
100-19-6

(4-nitrophenyl)ethanone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With hydrogen In methanol at 20℃; under 760.051 Torr; for 9h;100%
With hydrogenchloride; ammonium chloride In tetrahydrofuran; water at 45℃; for 2h; Sealed tube; Green chemistry;100%
With hydrogen In water at 50℃; under 750.075 Torr; for 1.5h;100%
83810-18-8

4-(2-methyl-1,3-dithian-2-yl)aniline

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With dihydrogen peroxide; iodine; sodium dodecyl-sulfate In water at 20℃; for 0.333333h; Micellar solution;100%
With Methylthio(bismethylthio)sulfonium hexachloroantimonate In dichloromethane at -77℃; for 0.0166667h;97%
With 2,4,4,6-Tetrabromo-2,5-cyclohexadien-1-one; dihydrogen peroxide In water; acetonitrile at 20℃; for 0.5h;96%
With hydrogen bromide; dihydrogen peroxide In acetonitrile at 25℃; for 6h;95%
14235-81-5

4-Ethynylaniline

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With gold(III) tribromide; water at 200℃; for 0.333333h; microwave irradiation;100%
With 5,10,15-tris(pentafluorophenyl)corrole cobalt(III) triphenyl phosphine; sulfuric acid; water In methanol at 80℃; for 12h;99%
With trifluorormethanesulfonic acid; water In 2,2,2-trifluoroethanol at 25 - 70℃; for 45h; Sealed tube; regioselective reaction;89%
1321455-52-0

1-(4-(tert-butyldimethylsilylamino)phenyl)ethanone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With silica gel In ethanol; water at 20℃; for 2h;100%
20062-24-2

4-azidoacetophenone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 20℃; chemoselective reaction;99%
With hydrogen; palladium In methanol; N,N-dimethyl-formamide at 20℃; under 6080.41 Torr; for 8h; Solvent; Temperature; Pressure; Inert atmosphere;99%
With ammonium hydroxide at 90℃; for 0.666667h;95%
13329-40-3

4-Iodoacetophenone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With ammonium hydroxide; copper(l) iodide; N,N-dimethylethylenediamine In dimethyl sulfoxide at 130℃; for 5h; Reagent/catalyst; Time; Sealed tube; Inert atmosphere;99%
Stage #1: 4-Iodoacetophenone With potassium phosphate; 2,2,2-trifluoroacetamide; N,N`-dimethylethylenediamine; copper(l) iodide In N,N-dimethyl-formamide at 45℃;
Stage #2: With methanol In N,N-dimethyl-formamide at 45℃; Further stages.;
98%
Stage #1: 4-Iodoacetophenone With copper(l) iodide; D-glucosamine hydrochloride; potassium carbonate In water; acetone at 90℃; for 0.166667h;
Stage #2: With ammonia In water; acetone at 90℃; for 28h;
96%
93453-80-6, 14572-89-5

1-(4-aminophenyl)ethanol

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With silica-supported Jones reagent In dichloromethane for 0.00269444h;98.8%
With bromopentacarbonylmanganese(I); N-methyl-N,N-di(2-pyridylmethyl)amine; acetone; sodium t-butanolate In toluene at 90℃; for 2h; Inert atmosphere; Schlenk technique; Darkness;98%
With N-Bromosuccinimide; β‐cyclodextrin In methanol; water; acetone at 20℃; for 10h;95%
103-84-4

Acetanilid

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With aluminium trichloride for 0.05h; Fries rearrangement; microwave irradiation;97%
With ytterbium trifluoromethanesulfonate; lithium perchlorate In nitromethane at 100℃; for 8h; Fries rearrangement;44%
With acetic anhydride; zinc(II) chloride
99-90-1

para-bromoacetophenone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With C24H32N2*ClCu; ammonia; potassium carbonate In 1-methyl-pyrrolidin-2-one; methanol at 90℃; under 5171.62 Torr; for 24h; Inert atmosphere;97%
With copper(ll) sulfate pentahydrate; ammonium hydroxide In PEG1000-DIL; methyl cyclohexane at 60℃; for 4h;97%
With ammonium hydroxide; potassium phosphate; 1-(5,6,7,8-tetrahydroquinolin-8-yl)-2-methylpropan-1-one; copper(I) bromide In dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere; Sealed tube;96%
232597-42-1

tert-butyl 4-acetylphenylcarbamate

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With water at 100℃; for 2.5h;97%

C18H29NO3Si

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 0 - 20℃;96%
121-44-8

triethylamine

540-37-4

p-aminoiodobenzene

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With dichloro bis(acetonitrile) palladium(II); tetrabutylammomium bromide; water; zinc(II) oxide In dimethyl sulfoxide at 100℃; for 16h;96%
With water; oxygen; zinc(II) oxide In acetonitrile at 20℃; Irradiation;59%
403-42-9

1-(4-fluorophenyl)ethanone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With dipotassium peroxodisulfate; sodium azide; water; silver carbonate In N,N-dimethyl-formamide at 120℃; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Sealed tube;96%
With sodium azide In dimethyl sulfoxide at 125℃; for 19h;25%
38063-81-9

p-aminoacetophenone oxime

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 20℃; for 0.0166667h; neat (no solvent);95%
With sodium periodate; silica gel In solid for 0.0416667h; Irradiation;83%
With perchloric acid; dihydrogen peroxide; potassium bromide; ammonium molybdate tetrahydrate In water at 20℃; for 2h;80%
With sulfuric acid In 1,4-dioxane; water for 0.416667h; Reflux;80%
18179-86-7

4,4'-diacetylazobenzene

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With aminomethyl polysterene resin formic acid salt; zinc In methanol for 0.266667h;95%
With polystyrene-CH2-NH3(+)HCO2(-); magnesium In methanol at 20℃; for 0.3h;94%
With aminomethylpolystyrene-supported formate; palladium on activated charcoal In methanol at 20℃; for 5h;94%
100-19-6

(4-nitrophenyl)ethanone

A

99-92-3

4-Aminoacetophenone

B

589-16-2

4-aminoethylbenzene

Conditions
ConditionsYield
With hydrogen In glycerol at 100℃; for 2h;A 95%
B n/a
With methanesulfonic acid; palladium, 5% on calcium carbonate, poisoned with lead; hydrogen In ethanol at 30℃; under 2585.81 Torr; for 22h; Reagent/catalyst; Sealed tube;A 66 %Chromat.
B 26 %Chromat.
100-19-6

(4-nitrophenyl)ethanone

56-81-5

glycerol

A

C11H13NO5

B

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With hydrogen at 100℃; for 2h;A n/a
B 95%
3419-18-9

4-aminobenzaldehyde oxime

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With C2H5NO2*C9H7NO*6H2O*Cl2Co; dihydrogen peroxide In methanol for 2.5h; Reflux;94%

2,2,2-trichloroethyl (4-acetylphenyl)carbamate

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With indium; ammonium chloride In ethanol for 3h; Heating;93%

potassium 4-acetylphenyltrifluoroborate

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With ammonium hydroxide; copper(ll) sulfate pentahydrate; sodium hydroxide In water at 25℃; for 24h;92%

2-methyl-2-(4-N-tert-butoxycarbonylphenyl)-1,3-dithiane

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With ammonium persulfate; Montmorillonite K-10 clay for 0.0333333h; microwave irradiation;90%

1-[4-({[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl]phenylmethylene}amino)phenyl]ethanone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran at 20℃;90%
589-16-2

4-aminoethylbenzene

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With nickel-doped graphene carbon nitride nanoparticles; air In ethanol at 25℃; for 8h; Irradiation; Green chemistry;90%
With air; Ag/AgBr/TiO2 nanotubes In neat (no solvent) at 20℃; for 12h; Irradiation; Green chemistry;48%
With oxygen; Mn-MgAl hydrotalcite at 135℃; under 760.051 Torr; for 5h;
99-91-2

para-chloroacetophenone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With copper(l) iodide; ammonia; C14H16N2O4; caesium carbonate at 120℃; for 24h; Sealed tube; Inert atmosphere;89%
With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation;88%
With ammonium sulfate; bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate at 100 - 110℃; for 12h;85%
1336-21-6

ammonium hydroxide

99-90-1

para-bromoacetophenone

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With copper(l) iodide In water at 200℃; for 2h; Autoclave;89%
With copper(ll) sulfate pentahydrate; potassium phosphate tribasic heptahydrate; water; Sucrose In water at 90℃; for 15h; Catalytic behavior; Green chemistry;75%
20062-24-2

4-azidoacetophenone

A

93453-80-6, 14572-89-5

1-(4-aminophenyl)ethanol

B

99-92-3

4-Aminoacetophenone

C

589-16-2

4-aminoethylbenzene

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 25℃; under 760.051 Torr; for 1.5h;A 5%
B 89%
C 6%

4-acetylphenylsilver

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With dipotassium peroxodisulfate; sodium azide; water; silver carbonate In N,N-dimethyl-formamide at 120℃; for 20h; Darkness; Sealed tube;89%
100-19-6

(4-nitrophenyl)ethanone

A

99-92-3

4-Aminoacetophenone

B

75-07-0

acetaldehyde

C

H2

H2

Conditions
ConditionsYield
With ethanol; titanium(IV) oxide for 0.25h; Irradiation;A 88%
B n/a
C n/a
120-72-9

indole

3340-78-1

2-phenyl-1,2,3,4-tetrahydroisoquinoline

100-19-6

(4-nitrophenyl)ethanone

A

1-(1H-indol-3-yl)-2-phenyl-1, 2, 3, 4-tetrahydroisoquinoline

B

99-92-3

4-Aminoacetophenone

Conditions
ConditionsYield
With Co(dmgH)2Cl2; Eosin Y In water; acetonitrile at 20℃; for 48h; Inert atmosphere; Irradiation; Sealed tube;A 87%
B 90 %Spectr.
108-24-7

acetic anhydride

99-92-3

4-Aminoacetophenone

2719-21-3

4-(N-acetylamino)acetophenone

Conditions
ConditionsYield
In dichloromethane at 20℃; Inert atmosphere;100%
In toluene at 20℃;96%
In 1,4-dioxane; water at 0 - 25℃; for 2.5h; Acetylation;95%
99-92-3

4-Aminoacetophenone

124-63-0

methanesulfonyl chloride

5317-89-5

4'-(methylsulfonylamino)acetophenone

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 23h; Inert atmosphere;100%
With pyridine In dichloromethane at 0 - 20℃; for 16h;98%
In dichloromethane at 20 - 25℃; for 1h; Large scale;96%
99-92-3

4-Aminoacetophenone

98-59-9

p-toluenesulfonyl chloride

5317-94-2

4-(p-toluenesulfonylamino)acetophenone

Conditions
ConditionsYield
With triethylamine In dichloromethane at 4℃;100%
In pyridine for 1h; Ambient temperature;96.6%
With pyridine In dichloromethane at 20℃; for 3h;96%
99-92-3

4-Aminoacetophenone

56759-32-1

1-(4-amino-3-bromophenyl)-ethanone

Conditions
ConditionsYield
With N-Bromosuccinimide In acetonitrile at 20℃; for 20h; Cooling with ice;100%
With hydrogen bromide In water; dimethyl sulfoxide at 85℃; for 4h;99%
With N-Bromosuccinimide at 20℃; for 0.0833333h; regioselective reaction;97%
99-92-3

4-Aminoacetophenone

(R)-1-(4-aminophenyl)ethanol

Conditions
ConditionsYield
With (S,S)-RuCl2(2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)(1,1-dianisyl-2-isopropyl-1,2-ethylenediamine); potassium tert-butylate; hydrogen In isopropyl alcohol at 26 - 30℃; under 6080 Torr; for 4h;100%
With N(CH2)3CHCPh2OBO(n-Oct)100%
With potassium tert-butylate; hydrogen In isopropyl alcohol; tert-butyl alcohol at 20℃; under 1875.19 - 3375.34 Torr; for 2.5h; enantioselective reaction;88%
99-92-3

4-Aminoacetophenone

4114-31-2

ethylhydrazine carboxylate

540757-28-6

N'-[1-(4-amino-phenyl)-ethylidene]-hydrazinecarboxylic acid ethyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 2h; Reflux; Inert atmosphere;100%
15930-53-7

6-bromo-3,4-methylenedioxybenzaldehyde

99-92-3

4-Aminoacetophenone

1206531-50-1

E-1-(4-((6-bromobenzo[d ][1,3]dioxol-5-yl)methyleneamino)-phenyl)ethanone

Conditions
ConditionsYield
In methanol100%
99-92-3

4-Aminoacetophenone

708-06-5

2-hydroxynaphthalene-1-carbaldehyde

C19H15NO2

Conditions
ConditionsYield
With triethylamine In ethanol for 1h; Milling;100%
99-92-3

4-Aminoacetophenone

2815-34-1, 1119702-25-8

2,5-dimethyl-piperazine

C22H26N6O2

Conditions
ConditionsYield
Stage #1: p-aminobenzophenone With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h;
Stage #2: 2,5-dimethyl-piperazine In water for 0.5h;
100%
99-92-3

4-Aminoacetophenone

16257-76-4

1-(benzenesulphonyl)-4-hydroxypyrrolidine-2-carboxylic acid

N-(4-acetylphenyl)-1-(benzenesulfonyl)-4-hydroxypyrrolidine-2-carboxamide

Conditions
ConditionsYield
With boric acid In toluene for 10h; Dean-Stark; Reflux;100%

4-hydroxy-1-(4-nitrophenylsulphonyl)pyrrolidine-2-carboxylic acid

99-92-3

4-Aminoacetophenone

N-(4-acetylphenyl)-4-hydroxy-1-(4-nitrobenzenesulfonyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With boric acid In toluene for 10h; Dean-Stark; Reflux;100%
201230-82-2

carbon monoxide

610-97-9

o-iodo-methyl-benzoic acid

99-92-3

4-Aminoacetophenone

40101-59-5

2-(4-acetylphenyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 1h; Schlenk technique;100%
99-92-3

4-Aminoacetophenone

88867-96-3

1-(4-nitrophenylsulphonyl)pyrrolidine-2-carboxylic acid

N-(4-acetylphenyl)-1-(4-nitrobenzenesulfonyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With boric acid In toluene for 10h; Dean-Stark; Reflux;99.98%

{benzoyl[(4-methylphenyl)sulfonyl]amino}acetic acid

99-92-3

4-Aminoacetophenone

N-(4-acetylphenyl)-2-[N-(4-methylbenzenesulfonyl)-1-phenylformamido]acetamide

Conditions
ConditionsYield
With boric acid In toluene for 10h; Dean-Stark; Reflux;99.98%
88425-46-1

N-benzenesulfonyl-L-proline

99-92-3

4-Aminoacetophenone

N-(4-acetylphenyl)-1-(benzenesulfonyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With boric acid In toluene for 10h; Dean-Stark; Reflux;99.97%

3-(1H-indol-2-yl)-2-[N-(4-nitrobenzenesulfonyl)-1-phenylformamido]propanoic acid

99-92-3

4-Aminoacetophenone

N-(4-acetylphenyl)-3-(1H-indol-2-yl)-2-[N-(4-nitrobenzenesulfonyl)-1-phenyl formamido]propanamide

Conditions
ConditionsYield
With boric acid In toluene for 10h; Dean-Stark; Reflux;99.97%

2-[N-(4-nitrobenzenesulfonyl)-1-phenylformamido]acetic acid

99-92-3

4-Aminoacetophenone

N-(4-acetylphenyl)-2-[N-(4-nitrobenzenesulfonyl)-1-phenylformamido]acetamide

Conditions
ConditionsYield
With boric acid In toluene for 10h; Dean-Stark; Reflux;99.58%

3-methyl-2-[N-(4-nitrobenzenesulfonyl)-1-phenylformamido]butanoic acid

99-92-3

4-Aminoacetophenone

N-(4-acetylphenyl)-3-methyl-2-[N-(4-nitrobenzenesulfonyl)-1-phenylformamido]butanamide

Conditions
ConditionsYield
With boric acid In toluene for 10h; Dean-Stark; Reflux;99.58%
20275-18-7

N--trans-4-hydroxy-L-proline

99-92-3

4-Aminoacetophenone

N-(4-acetylphenyl)-4-hydroxy-1-(4-methylbenzenesulfonyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With boric acid In toluene for 10h; Dean-Stark; Reflux;99.48%
91-56-5

indole-2,3-dione

99-92-3

4-Aminoacetophenone

94205-62-6

2-(4'-aminophenyl)-4-quinolinecarboxylic acid

Conditions
ConditionsYield
With water; potassium hydroxide In ethanol at 100℃;99%
With potassium hydroxide In ethanol Heating;86%
With potassium hydroxide In ethanol; water Pfitzinger reaction; Heating;85.9%
Stage #1: indole-2,3-dione With cetyltrimethylammonium hydroxide In water at 20℃; for 0.166667h; Pfitzinger Quinoline Synthesis; Sonication; Green chemistry;
Stage #2: p-aminobenzophenone In water at 35℃; for 4.5h; Temperature; Pfitzinger Quinoline Synthesis; Sonication; Green chemistry;
75%
With potassium hydroxide
541-41-3

chloroformic acid ethyl ester

99-92-3

4-Aminoacetophenone

5520-79-6

ethyl (4-acetylphenyl)carbamate

Conditions
ConditionsYield
With pyridine In acetone for 3h; Reflux;99%
99-92-3

4-Aminoacetophenone

79-22-1

methyl chloroformate

60677-43-2

methyl N-(4-acetylphenyl)carbamate

Conditions
ConditionsYield
With pyridine In acetone for 3h; Reflux;99%
With sodium hydroxide In 1,4-dioxane; water at 0 - 25℃; for 2.5h; alkoxycarbonylation;98%
With pyridine at 20℃; for 15h; Cooling;91%
99-92-3

4-Aminoacetophenone

99-91-2

para-chloroacetophenone

Conditions
ConditionsYield
Stage #1: p-aminobenzophenone With tert.-butylnitrite In acetonitrile at 20℃; Sandmeyer Reaction; Flow reactor;
Stage #2: With copper dichloride In ethylene glycol; acetonitrile at 82℃; Sandmeyer Reaction; Flow reactor;
99%
With N-chloro-succinimide; sodium nitrite In N,N-dimethyl-formamide at 20℃; for 6h;77%
With tert.-butylnitrite; copper dichloride In acetonitrile
With hydrogenchloride; potassium nitrite; dimethyl sulfoxide; copper(l) chloride In water at 35℃; for 0.333333h;82 % Chromat.
99-92-3

4-Aminoacetophenone

407-25-0

trifluoroacetic anhydride

24568-13-6

N-(4-acetylphenyl)-2,2,2-trifluoroacetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 10℃;99%
With triethylamine at 20℃; for 12h;80%
In N,N-dimethyl-formamide for 48h; Ambient temperature;73%
99-92-3

4-Aminoacetophenone

20062-24-2

4-azidoacetophenone

Conditions
ConditionsYield
Stage #1: p-aminobenzophenone With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h;
Stage #2: With sodium azide In water at 5℃;
99%
With tert.-butylnitrite; trimethylsilylazide In acetonitrile at 20℃; for 2h;95%
Stage #1: p-aminobenzophenone With hydrogenchloride In water at 0 - 5℃; for 0.166667h;
Stage #2: With 1-methyl-3-(2-[2-(1-methyl-1H-imidazol-3-ium-3-yl)ethyloxy]ethyl)-1H-imidazol-3-ium dinitrite In water for 0.166667h;
Stage #3: With sodium azide In water at 20℃; for 0.166667h; Ionic liquid;
95%
99-92-3

4-Aminoacetophenone

158198-05-1

3-phenylnorbornadiene-2-carbonyl chloride

3-Phenyl-bicyclo[2.2.1]hepta-2,5-diene-2-carboxylic acid (4-acetyl-phenyl)-amide

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane for 0.166667h; Heating;99%
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    Business Type:Lab/Research institutions

    Tel:+86-21-52196435

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  • 4-Aminoacetophenone

  • Casno:

    99-92-3

    4-Aminoacetophenone

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 88.0-100.0/Kilogram

    Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

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  •  Baoji Guokang Healthchem co.,ltd

     China (Mainland)  |  Contact Details

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    Tel:86-917-3909592

    Address:China

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Chemistry

p-Aminoacetophenone(99-92-3) exists as exists as yellow needle-like crystals with a special aromatic odor. p-Aminoacetophenone(99-92-3) is soluble in hot water, Alcohol, ether, dilute hydrochloric acid and dilute sulphuric acid, lightly soluble in benzene and cold water.
Molecular Structure:
Molecular Formula: C8H9NO.
Molecular Weight: 135.17.
Density: 1.451g/cm3.
Melting Point: 105 - 107 ℃.
Boiling Point: 293 ℃ at 760 mmHg
Flash Point: 94.3 ℃.

Uses

p-Aminoacetophenone(99-92-3) is mainly used as intermediate of antitussive drugs. p-Aminoacetophenone(99-92-3) is also used to determine Palladium and Vitamin B1.

Toxicity Data With Reference

1.   

ipr-mus LD50:381 mg/kg

   GEPHDP    General Pharmacology. 14 (1983),465. NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
2.   

ipr-rat LD50:260 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 80 (1944),31.
3.   

orl-mus LD50:596 mg/kg

   GEPHDP    General Pharmacology. 14 (1983),465.
4.   

ipr-mus LD50:300 mg/kg

   NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
5.   

orl-bwd LD50:133 mg/kg

   AECTCV    Archives of Environmental Contamination and Toxicology. 12 (1983),355.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. See also AROMATIC AMINES.
Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
22: Harmful if swallowed 
36/37/38: Irritating to eyes, respiratory system and skin 
20/21/22: Harmful by inhalation, in contact with skin and if swallowed 
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36: Wear suitable protective clothing 
WGK Germany: 3
RTECS: AM5500000
TSCA: T
HS Code: 29223900