The anion of 4-dimethoxymethylpyridine. A convenient synthesis of some 4-pyridyl ketones

Article abstract of DOI:10.1080/00397919308009855

n-Butyllithium at -78°C abstracts the methine proton from 4-dimethoxymethylpyridine. The anion reacts efficiently with electrophiles. Simple ketal products can be readily hydrolysed to 4-pyridyl ketones.

Full text of DOI:10.1080/00397919308009855

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Synthetic Communications: An
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The Anion of 4-
Dimethoxymethylpyridine.
A Convenient Synthesis of
Some 4-Pyridyl Ketones A
convienient synthesis of some
4-pyridyl ketones
Peter W. Sheldrake a
a Smith Kline Beecham Pharmaceuticals Old Powder
Mills , Nr Leigh Tonbridge, Kent, TN 11 9AN
Published online: 16 Feb 2007.
To cite this article: Peter W. Sheldrake (1993) The Anion of 4-
Dimethoxymethylpyridine. A Convenient Synthesis of Some 4-Pyridyl Ketones A
convienient synthesis of some 4-pyridyl ketones, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 23:14,
1967-1971, DOI: 10.1080/00397919308009855
To link to this article: http://dx.doi.org/10.1080/00397919308009855
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