Protecting group controlled diastereoselective reduction of diprotected α,α-bis(hydroxymethyl) ketones derived from THYM*, using the DIBALH / MgBr2 system

DOI: 10.1016/S0040-4039(00)73940-2

Source and publish data:

Tetrahedron Letters p. 5483 - 5486 (1993)

Update date:2022-08-02

Topics:

Authors:

Guanti, Giuseppe

Banfi, Luca

Riva, Renata

Teresa Zannetti

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Article abstract of DOI:10.1016/S0040-4039(00)73940-2

The reduction of diprotected α,α-bis(hydroxymethyl)ketones 5, derived from the novel chiral building blocks THYM*1 and BHYMA*2 has been realized with good to excellent stereoselectivity (from 85:15 to 97:3), through a appropriate choice of the two protect

Full text of DOI:10.1016/S0040-4039(00)73940-2

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