Protecting group controlled diastereoselective reduction of diprotected α,α-bis(hydroxymethyl) ketones derived from THYM*, using the DIBALH / MgBr2 system

Article abstract of DOI:10.1016/S0040-4039(00)73940-2

The reduction of diprotected α,α-bis(hydroxymethyl)ketones 5, derived from the novel chiral building blocks THYM*1 and BHYMA*2 has been realized with good to excellent stereoselectivity (from 85:15 to 97:3), through a appropriate choice of the two protect