Bioorganic and Medicinal Chemistry Letters p. 35 - 40 (1998)
Update date:2022-08-05
Topics:
Vaccaro, Wayne D.
Sher, Rosy
Davis Jr., Harry R.
The asymmetric synthesis of a glucuronide conjugate of the 2-azetidinone cholesterol absorption inhibitor Sch 48461 was accomplished to confirm the structure of a metabolite isolated from in vivo sources. Key features of this article include the asymmetric synthesis of 2-azetidinones by Evan's chiral oxazolidinone methodology and glucuronide formation by a Mitsunobu protocol.
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