Benzyl cation initiated intramolecular cyclizations. Synthesis of 1-azabicyclo[3.2.1]octene derivatives

DOI: 10.1002/prac.19983400511

Source and publish data:

Journal fur Praktische Chemie - Chemiker-Zeitung p. 472 - 475 (1998)

Update date:2022-08-03

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Authors:

Csuzdi, Emese

Pallagi, Istvan

Sziraki, Istvan

Solyom, Sandor

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Article abstract of DOI:10.1002/prac.19983400511

Benzyl cation inititiated intramolecular cyclization reactions with conjugated C-C double bonds were performed providing rac. endo-exo isomers of 1-azabicyclo[3.2.1]octenes (2 and 3). Formation of the endo isomer 2 is favoured. Compounds 2 possess dopamine uptake inhibitory effect with an additional selective MAO-B enzyme inhibitory potential. The remarkable in vitro effects do not correspond to in vivo antidepressant activity. Johann Ambrosius Barth 1998.

Full text of DOI:10.1002/prac.19983400511

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