Development of a stereoselective and chemoselective approach to trans-2,3-disubstituted-4-chromanones

DOI: 10.1002/jhet.5570310617

Source and publish data:

Journal of Heterocyclic Chemistry p. 1401 - 1405 (1994)

Update date:2022-08-04

Topics: Characterization Optimization Protecting groups Retrosynthetic analysis Scale-up Stereochemistry Control Chemoselectivity Work-up and purification Verification of Stereochemistry

Authors:

Chambers

Marfat Marfat

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Article abstract of DOI:10.1002/jhet.5570310617

A direct synthesis of chromanones 10 and 11 was achieved in five steps from acetophenone 1 in an overall yield of 37% and 53% respectively. The requisite 2,3-trans stereochemistry in chromanone 10 and 11 was set by a chemoselective and stereoselective con

Full text of DOI:10.1002/jhet.5570310617

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