Remote acyclic diastereocontol involving a bicyclic metal chelate. High 1,5 asymmetric induction in the hydride reduction of δ-hydroxy ketones

DOI: 10.1016/S0040-4039(00)73275-8

Source and publish data:

Tetrahedron Letters p. 4891 - 4894 (1994)

Update date:2022-09-26

Topics:

Authors:

Zhang, Han-Cheng

Costanzo, Michael J.

Maryanoff, Bruce E.

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Article abstract of DOI:10.1016/S0040-4039(00)73275-8

A variety of reducing agents was explored to effect stereoselective reduction of acyclic δ-hydroxy ketone 3a; R-Alpine-Hydride provided high anti stereoselectivity (anti:syn = 7:1). Reduction of 3b in CH₂Cl₂ with R-Alpine-Hydride or

Full text of DOI:10.1016/S0040-4039(00)73275-8

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