Welcome to LookChem.com Sign In|Join Free
  • or

136-47-0

Post Buying Request

136-47-0 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Factory supply Tetracaine hydrochloride cas 136-47-0
Cas No: 136-47-0
USD $ 500.0-800.0 / Kilogram 1 Kilogram 5000 Kilogram/Month Kono Chem Co.,Ltd Contact Supplier
Tetracaine hcl / tetracaine Hydrochloride white powder cas 136-47-0 factory supply
Cas No: 136-47-0
USD $ 99.0-100.0 / Kilogram 1 Kilogram 10 Metric Ton/Month Metric Ton/Day Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
ISO supply 136-47-0 STOCK Medicine grade tetracaine hydrochloride 99% tetracaine
Cas No: 136-47-0
USD $ 130.0-160.0 / Kilogram 1 Kilogram 5000 Kilogram/Month Xi'an Harmonious Natural Bio-Technology Co., Ltd. Contact Supplier
Tetracaine hydrochloride CAS NO.136-47-0
Cas No: 136-47-0
USD $ 2.0-2.0 / Gram 100 Gram 100 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Made in china Tetracaine Hydrochloride 136-47-0 for Pain Killer in india
Cas No: 136-47-0
USD $ 6.0-10.0 / Gram 10 Gram 100000 Kilogram/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Top Supplier Tetracaine hydrochloride/ Tetracaine
Cas No: 136-47-0
No Data 1 Kilogram 100000 Kilogram/Year Shanghai Upbio Tech Co.,Ltd Contact Supplier
Tetracaine hcl powder 99% Manufactuered in China best quality CAS.136-47-0
Cas No: 136-47-0
No Data 1 Kilogram 50000 Kilogram/Day Wuhan Monad Medicine Tech Co.,LTD Contact Supplier
High quality Tetracaine hydrochloride Powder 99% CAS 136-47-0 Lianxu
Cas No: 136-47-0
USD $ 10.0-20.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Shanxi LX New Material Co., Ltd. Contact Supplier
Tetracaine HCL powder
Cas No: 136-47-0
No Data No Data Metric Ton/Day Wuhan Godbullraw Chemical Co.,ltd Contact Supplier
China Supplier Sell White Powder CAS 136-47-0 Tetracaine Hydrochloride HCl Tetracaine
Cas No: 136-47-0
USD $ 9.0-65.0 / Kilogram 1 Kilogram 10000 Kilogram/Week Xi'an SENYI New Material Technology Co., Ltd Contact Supplier

136-47-0 Usage

Uses

anesthetic (local)

Therapeutic Function

Local anesthetic

Chemical Properties

White Solid

Manufacturing Process

4-Butylaminobenzoic acid is produced by boiling an aqueous solution of the sodium salt of 4-aminobenzoic acid with n-butyl-bromide. It forms a colorless crystalline powder melting at 153-154°C.Equimolecular quantities of 4-butylaminobenzoic acid and the hydrochloride of β-dimethylaminoethanol are suspended in 10 times their joint weight of toluene. The mixture is saturated with hydrochloric acid gas and heated in an oil bath at about 150°C while a current of hydrochloric acid, gas is slowly passed through the mixture so that toluene slowly distils. Along with toluene the water produced by the esterification distils. After heating for about 10 hours the mixture is cooled and water is added until the salt is dissolved. The layer of toluene is separated and the ester base precipitated from the aqueous solution by means of a solution of sodium carbonate. By dissolving the base in ether, drying the ether solution separated over potassium carbonate and adding alcoholic hydrochloric acid, to the solution until it is neutral to litmus, the monohydrochloride is obtained in the form of a colorless crystalline powder which, when recrystallized from alcohol, melts at 147-148°C.The 4-butylaminobenzoic acid β-di-methylaminoethylester monohydrochloride is a colorless crystalline powder, which is easily soluble in water. The solution may be sterilized by boiling without decomposition having to be feared. The base can be precipitated from the aqueous solution of the salt; it is at first in the form of an oil but soon solidifies, forms colorless crystals and melts at 43°C. The picrate melts at 120°C. When treated with oxalic acid, the base forms a neutral oxalate which is easily soluble in water and an acid oxalate which is very difficultly soluble in cold water.In practice it is usually used as hydrochloride salt.

Application

Tetracaine hydrochloride is also known as ropivacaine hydrochloride, pantocaine, pantocaine and four ropivacaine hydrochloride. It is easily soluble in water and ethanol, but insoluble in ether, benzene. Tetracaine hydrochloride is a local anesthetic with long-acting ester. In addition, procaine is widely used in clinical, but because of its poor permeability and poor narcotic performance, a small tetracaine was found in 1930 found. Tetracaine hydrochloride can be used for topical anesthesia, and 0.05%-0.1% tetracaine hydrochloride can provide long-term and good effect of surface anesthesia. Meanwhile, tetracaine hydrochloride is still widely used in ophthalmic surface anesthesia, which has a long time for surface anesthesia and sensory resistance.

Uses

Tetracaine hydrochloride is a local anesthetic used topically in opthalmology.

Uses

Tetracaine hydrochloride is used as topical and local anesthetic.

Originator

Anestesia topica,Miro

Side Effects

Common side effects include a brief period of burning at the site of use.Allergic reactions may uncommonly occur. Long term use is generally not recommended as it may slow healing of the eye. It is unclear if use during pregnancy is safe for the baby. Tetracaine hydrochloride is in the ester-type local anesthetic family of medications. It works by blocking the sending of nerve impulses.

Contact allergens

Amethocaine is a local anesthetic used in dental surgery. It was reported as an agent of contact dermatitis in dentists or dental nurses and in ophthalmologists
InChI:InChI=1/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H

136-47-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (T1688)  Tetracaine Hydrochloride  >98.0%(HPLC)(T) 136-47-0 5g 310.00CNY Detail
TCI America (T1688)  Tetracaine Hydrochloride  >98.0%(HPLC)(T) 136-47-0 25g 845.00CNY Detail
Sigma-Aldrich (PHR1129)    pharmaceutical secondary standard; traceable to USP and PhEur 136-47-0 PHR1129-1G 732.19CNY Detail
Sigma-Aldrich (Y0001002)  Tetracaine for system suitability  European Pharmacopoeia (EP) Reference Standard 136-47-0 Y0001002 1,880.19CNY Detail
Sigma-Aldrich (T0500000)  Tetracainehydrochloride  European Pharmacopoeia (EP) Reference Standard 136-47-0 T0500000 1,880.19CNY Detail
USP (1650006)  Tetracainehydrochloride  United States Pharmacopeia (USP) Reference Standard 136-47-0 1650006-200MG 4,581.72CNY Detail
Sigma (T7508)  Tetracainehydrochloride  ≥99% 136-47-0 T7508-5G 526.50CNY Detail
Sigma (T7508)  Tetracainehydrochloride  ≥99% 136-47-0 T7508-25G 954.72CNY Detail
Sigma (T7508)  Tetracainehydrochloride  ≥99% 136-47-0 T7508-100G 3,006.90CNY Detail

136-47-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Tetracaine hydrochloride

1.2 Other means of identification

Product number -
Other names Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:136-47-0 SDS

136-47-0Synthetic route

amethocaine
94-24-6

amethocaine

tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; ethyl acetate94%
2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

ethyl 4-(N-butylamino)benzoate
94-32-6

ethyl 4-(N-butylamino)benzoate

tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium methylate In water at 130℃; for 8h;85%
2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

N-(n-butyl)-4-methoxycarbonylaniline
71839-12-8

N-(n-butyl)-4-methoxycarbonylaniline

tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

Conditions
ConditionsYield
Stage #1: 2-(N,N-dimethylamino)ethanol; N-(n-butyl)-4-methoxycarbonylaniline With sodium methylate at 130℃; for 8h;
Stage #2: With hydrogenchloride
83%
2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

butyraldehyde
123-72-8

butyraldehyde

tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

Conditions
ConditionsYield
Stage #1: 2-(N,N-dimethylamino)ethanol; 4-amino-benzoic acid; butyraldehyde With hydrogen at 40 - 45℃; under 2250.23 Torr; for 3h; Autoclave; Large scale;
Stage #2: With dmap In 5,5-dimethyl-1,3-cyclohexadiene for 4h; Reflux; Large scale;
Stage #3: With hydrogenchloride In ethanol; tert-butyl methyl ether; water at 45℃; pH=3 - 4; Reagent/catalyst; Temperature; Pressure; Solvent; Large scale;
75%
N-(4-ethoxycarbonylphenyl)butyramide
71134-92-4

N-(4-ethoxycarbonylphenyl)butyramide

tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dihydridocarbonyl(1,1,1-tris(diphenylphosphinomethyl)ethane)ruthenium(II) complex; hydrogen; toluene-4-sulfonic acid; boron trifluoride diethyl etherate / tetrahydrofuran / 20 h / 120 °C / 38002.6 Torr / Glovebox; Autoclave; Inert atmosphere
2: sodium methylate; hydrogenchloride / water / 8 h / 130 °C
View Scheme
4-nitrobenzoic acid 2-(dimethylamino)ethyl ester
38152-22-6

4-nitrobenzoic acid 2-(dimethylamino)ethyl ester

tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iron; acetic acid / 8 h / 30 °C
2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C
3: hydrogenchloride / ethyl acetate; water
View Scheme
4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dichloromethane / 2 h / 0 °C
2: iron; acetic acid / 8 h / 30 °C
3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 °C
4: hydrogenchloride / ethyl acetate; water
View Scheme
4-Bromobenzoic acid
586-76-5

4-Bromobenzoic acid

tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: copper / water; N,N-dimethyl-formamide / 25 h / 130 °C / Autoclave
2.1: sulfuric acid / 5,5-dimethyl-1,3-cyclohexadiene / Reflux
2.2: 20 - 25 °C / pH 3 - 4
View Scheme
2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

4-(N-butylamino)benzoic acid
4740-24-3

4-(N-butylamino)benzoic acid

tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

Conditions
ConditionsYield
Stage #1: 2-(N,N-dimethylamino)ethanol; 4-(N-butylamino)benzoic acid With sulfuric acid In 5,5-dimethyl-1,3-cyclohexadiene Reflux;
Stage #2: With hydrogenchloride In water; isopropyl alcohol at 20 - 25℃; pH=3 - 4;
22 g
tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

tetramethylammonium trifluoromethanethiolate

tetramethylammonium trifluoromethanethiolate

2-(dimethylamino)ethyl 4-(butyl(trifluoromethyl)amino)benzoate

2-(dimethylamino)ethyl 4-(butyl(trifluoromethyl)amino)benzoate

Conditions
ConditionsYield
Stage #1: tetracaine hydrochloride; tetramethylammonium trifluoromethanethiolate In acetonitrile at 20℃;
Stage #2: With silver fluoride In acetonitrile at 50℃; for 4h;
97%
tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

2-(dimethylamino)ethyl 4-(butylamino)-3-chlorobenzoate
1344028-77-8

2-(dimethylamino)ethyl 4-(butylamino)-3-chlorobenzoate

Conditions
ConditionsYield
With N-chloro-succinimide In acetonitrile for 24h; Reflux;75%
With N-chloro-succinimide In acetonitrile for 24h; Reflux;75%
tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

A

2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

B

4-(N-butylamino)benzoic acid
4740-24-3

4-(N-butylamino)benzoic acid

Conditions
ConditionsYield
With water Thermodynamic data; Rate constant; var. pH-values;
tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

2-dimethylaminoethyl 4-(n-butylamino)benzoate β-cyclodextrin
150398-16-6

2-dimethylaminoethyl 4-(n-butylamino)benzoate β-cyclodextrin

Conditions
ConditionsYield
aq. buffer;
tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

cyclomaltooctaose
17465-86-0

cyclomaltooctaose

2-dimethylaminoethyl 4-(n-butylamino)benzoate γ-cyclodextrin
150398-18-8

2-dimethylaminoethyl 4-(n-butylamino)benzoate γ-cyclodextrin

Conditions
ConditionsYield
aq. buffer;
tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

alpha cyclodextrin
10016-20-3

alpha cyclodextrin

2-dimethylaminoethyl 4-(n-butylamino)benzoate α-cyclodextrin
150398-13-3

2-dimethylaminoethyl 4-(n-butylamino)benzoate α-cyclodextrin

Conditions
ConditionsYield
aq. buffer;
bovine β-lactoglobulin isoform A

bovine β-lactoglobulin isoform A

tetracaine hydrochloride
136-47-0

tetracaine hydrochloride

1:1 complex of bovine β-lactoglobulin isoform A and tetracaine hydrochloride

1:1 complex of bovine β-lactoglobulin isoform A and tetracaine hydrochloride

Conditions
ConditionsYield
at 25℃; pH=7.5;
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 136-47-0