Tetrahedron p. 11153 - 11166 (1994)
Update date:2022-08-03
Topics: Synthesis Efficient DNA Polymerase α Expeditious Formal Synthesis Aphidicolin
Toyota, Masahiro
Nishikawa, Youichi
Fukumoto, Keiichiro
An expeditious and efficient formal total synthesis of an antiviral and antitumor tetracyclic diterpene aphidicolin (1) has been achieved. An intramolecular Heck reaction (7→6) and an intramolecular Diels-Alder reaction (4→3) were utilized for the key ste
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