Aphidicolin synthesis (II) - An expeditious and efficient formal synthesis of (+)-aphidicolin

DOI: 10.1016/S0040-4020(01)89418-7

Source and publish data:

Tetrahedron p. 11153 - 11166 (1994)

Update date:2022-08-03

Topics: Synthesis Efficient DNA Polymerase α Expeditious Formal Synthesis Aphidicolin

Authors:

Toyota, Masahiro

Nishikawa, Youichi

Fukumoto, Keiichiro

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Article abstract of DOI:10.1016/S0040-4020(01)89418-7

An expeditious and efficient formal total synthesis of an antiviral and antitumor tetracyclic diterpene aphidicolin (1) has been achieved. An intramolecular Heck reaction (7→6) and an intramolecular Diels-Alder reaction (4→3) were utilized for the key ste

Full text of DOI:10.1016/S0040-4020(01)89418-7

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