Synthesis and biological evaluation of novel cyclic enediyne compounds related to dynemicin A as antitumor agents

DOI: 10.1248/cpb.45.125

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 125 - 133 (1997)

Update date:2022-08-05

Topics:

Authors:

Unno, Ryoichi

Michishita, Hisashi

Inagaki, Hideaki

Baba, Yutaka

Jomori, Takahito

Nishikawa, Toshio

Isobe, Minoru

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Article abstract of DOI:10.1248/cpb.45.125

Novel cyclic enediyne compounds, which are simple functional analogs of dynemicin A (1) having the bicyclo[7.3.1]tridec-4-ene-2,6-diyne system, were synthesized and evaluated for the DNA-cleaving ability, in vitro cytotoxicity and in vivo antitumor activi

Full text of DOI:10.1248/cpb.45.125

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