A New Approach to Functionalized Cyclobutanes: Stereoselective Synthesis of the Enantiomers of Grandisol and Fraganol

Article abstract of DOI:10.1016/0957-4166(95)00141-B

Enantiomerically enriched (+)-grandisol and (+)-fraganol were synthesized using as the key step a new stereoselective synthesis of cyclobutanes fused to γ-lactones by a stereochemically-controlled intramolecular alkylation of α-benzenesulfonyl-γ-lactones.This method provides a way to synthesize the enantiomers in a straightforward manner.