Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA: Cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring

DOI: 10.1016/S0960-894X(97)10191-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 81 - 86 (1998)

Update date:2022-08-02

Topics:

Authors:

Tanaka, Akira

Terasawa, Takeshi

Hagihara, Hiroyuki

Kinoshita, Takayoshi

Sakuma, Yuri

Ishibe, Noriko

Sawada, Masae

Takasugi, Hisashi

Tanaka, Hirokazu

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)10191-3

The synthesis, single crystal X-ray structural analysis, and biological activity of FR186054 (2c), a new, potent, orally efficacious inhibitor of acyl-CoA: cholesterol O-acyltransferase (ACAT), containing a pyrazole ring are described. This compound displ

Full text of DOI:10.1016/S0960-894X(97)10191-3

Products guided by the article

Product name:Carbamic acid, [6-methyl-2,4-bis(methylthio)-3-pyridinyl]-, phenyl ester

Cas No:166253-17-4

R&D Labs maybe for 166253-17-4

Shanghai Dynamic Industrial Co.,Ltd.

website:http://www.shdynamic.com

Contact:86-021 3392 6680

Address:Room 805 Information Tower, No.1403 Minsheng Road, Pudong New Area, Shanghai 200135, P. R. China
Jiangxi Huashi Pharmaceutical Co., Ltd

Contact:+86-795-4509628

Address:No.199, Ningbo Avenue, Fengxin industrial park, Fengxin county, Yichun city, Jiangxi
Shandong Yuanli Science and Technology Co., Ltd.

Contact:86-0536-6777557

Address:Zhuliu Industiral Park,Changle County
SHANDONG CREDAGRI CHEMICAL CO., LTD.

Contact:+86-531-88872050

Address:ROOM 601A, BUILDING 2, SHUNTAI SQUARE, NO. 2000 SHUNHUA ROAD, HI-TECH DEVELOPMENT ZONE, JINAN, CHINA.
taicang liyuan chemical co,.ltd

website:http://www.tcliyuanchem.com/productse.php

Contact:86-512-53539583

Address:Room 804,Huaxu Building,No.95,Renmin South Road,Taicang city,Jiangsu Province,China

Relevant to this article

An efficient and scalable synthesis of 2,4-di-N-acetyl-l-altrose (l-2,4-Alt-diNAc)

Doi:10.1039/d1ra01070k
(2021)
Electrophilic Reactions of Carbenoids. Synthesis of Fused Heterocyclic Systems via Intramolecular Nucleophilic Substitution of Carbenoids

Doi:10.1021/jo00122a046
(1995)
General and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes

Doi:10.1002/chem.201303511
(2013)
Doi:10.1039/jr9480001867
(1948)
Additions of Organocopper Reagents and Heteroatom Nucleophiles to l-Phenylseleno-2-(p-toluenesulfonyl)ethyne. Preparation of Vinyl and Allenic Sulfones and Formation of Michael, Anti-Michael, and Rearrangement Products

Doi:10.1021/jo981224r
(1998)
Directed synthesis of fluorine containing 2,3-dihydrobenzo[b][1,4]oxathiine derivatives from polyfluoroarenes

Doi:10.1016/j.jfluchem.2020.109592
(2020)

Article Doi