Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA: Cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring

DOI: 10.1016/S0960-894X(97)10191-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 81 - 86 (1998)

Update date:2022-08-02

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Authors:

Tanaka, Akira

Terasawa, Takeshi

Hagihara, Hiroyuki

Kinoshita, Takayoshi

Sakuma, Yuri

Ishibe, Noriko

Sawada, Masae

Takasugi, Hisashi

Tanaka, Hirokazu

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Article abstract of DOI:10.1016/S0960-894X(97)10191-3

The synthesis, single crystal X-ray structural analysis, and biological activity of FR186054 (2c), a new, potent, orally efficacious inhibitor of acyl-CoA: cholesterol O-acyltransferase (ACAT), containing a pyrazole ring are described. This compound displ

Full text of DOI:10.1016/S0960-894X(97)10191-3

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Product name:Carbamic acid, [6-methyl-2,4-bis(methylthio)-3-pyridinyl]-, phenyl ester

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