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Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA: Cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring

DOI: 10.1016/S0960-894X(97)10191-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 81 - 86 (1998)

Update date:2022-08-02

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Authors:

Tanaka, AkiraTanaka, Akira

Terasawa, TakeshiTerasawa, Takeshi

Hagihara, HiroyukiHagihara, Hiroyuki

Kinoshita, TakayoshiKinoshita, Takayoshi

Sakuma, YuriSakuma, Yuri

Ishibe, NorikoIshibe, Noriko

Sawada, MasaeSawada, Masae

Takasugi, HisashiTakasugi, Hisashi

Tanaka, HirokazuTanaka, Hirokazu

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Article abstract of DOI:10.1016/S0960-894X(97)10191-3

The synthesis, single crystal X-ray structural analysis, and biological activity of FR186054 (2c), a new, potent, orally efficacious inhibitor of acyl-CoA: cholesterol O-acyltransferase (ACAT), containing a pyrazole ring are described. This compound displ

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Full text of DOI:10.1016/S0960-894X(97)10191-3

Products guided by the article

Product name:Carbamic acid, [6-methyl-2,4-bis(methylthio)-3-pyridinyl]-, phenyl ester

Cas No:166253-17-4

166253-17-4

R&D Labs maybe for 166253-17-4

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