A Practical Synthesis of an HIV Protease Inhibitor Intermediate - Diastreoselective Epoxide Formation from Chiral α-Aminoaldehydes

DOI: 10.1016/0040-4020(95)00309-V

Source and publish data:

Tetrahedron p. 6397 - 6410 (1995)

Update date:2022-08-04

Topics:

Authors:

Ng, John S.

Przybyla, Claire A.

Liu, Chin

Yen, Joe C.

Muellner, Frank W.

Weyker, Cara L.

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Article abstract of DOI:10.1016/0040-4020(95)00309-V

A practical and efficient synthesis of an HIV protease inhibitor intermediate has been developed based on the diastereoselective epoxide formation from a chiral α-aminoaldehyde and an in situ generated halomethyllithium reagent.

Full text of DOI:10.1016/0040-4020(95)00309-V

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