Baker's yeast reduction of prochiral γ-nitroketones: Enantioselective synthesis of (S)-4-nitroalcohols

Article abstract of DOI:10.1016/0040-4020(94)01056-6

The baker's yeast reduction of seven different prochiral nitroketones 1a-g occurred on the re face of the carbonyl group, thus affording the (S)-nitroalcohols 2a-g, with different level of enantioselectivity (e.e. 15-99%). The best results (e.e. = 99%) we