A convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils

Article abstract of DOI:10.1016/0040-4039(95)01238-D

A general and convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils via 1,5-dialkyl-6-(methylsulfonyl)uracils 1 and 1,5-dialkyl-6-(methylsulfinyl)-2-thiouracils 2, respectively, has been described. The compounds 1 and 2 were synthesized from ethyl 2-alkyl-3,3-di(methylthio)acrylates 3 in five steps in good yields.