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28319-77-9

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  • Health supplement Alpha GPC 50% 80% 99% CAS 28319-77-9for nootropic

    Cas No: 28319-77-9

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28319-77-9 Usage

Description

Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine.

Chemical Properties

White waxy solid

Originator

Sandoz; Italfarmaco (Italy)

Uses

Different sources of media describe the Uses of 28319-77-9 differently. You can refer to the following data:
1. sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.
2. L-α-Glycerophosphorylcholine has been used to rescue choline auxotrophy. It has also been used for the synthesis of glycerophospholipids.

Definition

ChEBI: A member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells.

Brand name

Delecit

General Description

L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.

Flammability and Explosibility

Notclassified

Biochem/physiol Actions

Increases inositol phosphate formation.

Check Digit Verification of cas no

The CAS Registry Mumber 28319-77-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,3,1 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 28319-77:
(7*2)+(6*8)+(5*3)+(4*1)+(3*9)+(2*7)+(1*7)=129
129 % 10 = 9
So 28319-77-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/m1/s1

28319-77-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name choline alfoscerate

1.2 Other means of identification

Product number -
Other names Choline alfoscerate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28319-77-9 SDS

28319-77-9Synthetic route

(2R)-3-chloro-1,2-propanediol
57090-45-6

(2R)-3-chloro-1,2-propanediol

phosphorylcholine chloride
107-73-3

phosphorylcholine chloride

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
Stage #1: phosphorylcholine chloride With potassium hydroxide In methanol for 1h;
Stage #2: (2R)-3-chloro-1,2-propanediol In methanol at 65℃; for 16h; Temperature;
99%
Stage #1: phosphorylcholine chloride With potassium hydroxide In ethanol for 0.5h;
Stage #2: (2R)-3-chloro-1,2-propanediol In ethanol at 75 - 85℃; for 6h;
79.6%
(R)-3-glycerylcycloethyl phosphate

(R)-3-glycerylcycloethyl phosphate

trimethylamine
75-50-3

trimethylamine

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
In ethanol at 20℃; for 5h;92.11%
(R)-1,2-diacetoxy glycerylphosphoryl choline
54672-38-7

(R)-1,2-diacetoxy glycerylphosphoryl choline

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
With potassium carbonate In methanol at 20℃; for 0.0833333h;91%
(2R)-3-chloro-1,2-propanediol
57090-45-6

(2R)-3-chloro-1,2-propanediol

phosphorylcholine chloride potassium salt

phosphorylcholine chloride potassium salt

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
at 60 - 65℃; for 48h; Temperature;78.6%
(2R)-3-chloro-1,2-propanediol
57090-45-6

(2R)-3-chloro-1,2-propanediol

C5H13NO4P(1-)*Cl(1-)*2Na(1+)

C5H13NO4P(1-)*Cl(1-)*2Na(1+)

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
at 80 - 85℃; for 50h;77.8%
In ethanol Reflux;7.8 g
C8H21NO6P(1+)*Cl(1-)

C8H21NO6P(1+)*Cl(1-)

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
With 717 type ion exchange resin In ethanol; water at 0℃; for 4h;77%
phosphorylcholine chloride potassium salt

phosphorylcholine chloride potassium salt

(2S)-3,4-dimethoxybenzylglycidol

(2S)-3,4-dimethoxybenzylglycidol

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
In methanol; water Solvent; Reflux;72.3%
(R)-4-bromomethyl-2-methyl-2-ethyl-1,3-dioxolane

(R)-4-bromomethyl-2-methyl-2-ethyl-1,3-dioxolane

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
Stage #1: (R)-4-bromomethyl-2-methyl-2-ethyl-1,3-dioxolane With sodium hydroxide In isopropyl alcohol at 82℃; for 30h;
Stage #2: With sulfuric acid In ethanol; water; isopropyl alcohol
67.9%
phosphorylcholine chloride
107-73-3

phosphorylcholine chloride

(R)-oxiranemethanol
57044-25-4

(R)-oxiranemethanol

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
In ethanol at 75 - 85℃; for 12h;67.5%
C9H15IO2

C9H15IO2

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
Stage #1: C9H15IO2 With potassium hydroxide In ethanol at 85℃; for 15h;
Stage #2: With hydrogenchloride In methanol; ethanol; water
66.5%
phosphorylcholine chloride potassium salt

phosphorylcholine chloride potassium salt

(R)-4-chloromethyl-2,2-dimethyl-1,3-dioxolane
57044-24-3

(R)-4-chloromethyl-2,2-dimethyl-1,3-dioxolane

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
Stage #1: (R)-4-chloromethyl-2,2-dimethyl-1,3-dioxolane With potassium carbonate In methanol at 65℃; for 18h;
Stage #2: phosphorylcholine chloride potassium salt With hydrogenchloride In methanol; water
65.1%
all cis-5,8,11,14,17-eicosapentaenoic acid
10417-94-4

all cis-5,8,11,14,17-eicosapentaenoic acid

L-dipalmitoylphosphatidylcholine
63-89-8

L-dipalmitoylphosphatidylcholine

A

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

B

1-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-sn-glycero-3-phosphocholine

1-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-sn-glycero-3-phosphocholine

C

PC(36:5)

PC(36:5)

Conditions
ConditionsYield
With Rhizomucor miehei lipase Product distribution; Substitution; hydrolysis; Enzymatic reaction;
(-)(R)-glycerol-1.2-isopropylidene ether-3--sulfate

(-)(R)-glycerol-1.2-isopropylidene ether-3--sulfate

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
With water at 20 - 25℃; Behandlung des Reaktionsprodukts mit BaCO3;
(S)-glycidyl phosphorylcholine

(S)-glycidyl phosphorylcholine

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
With water; potassium carbonate for 5h; Reflux;0.13 g
siladenoserinol A
1417365-52-6

siladenoserinol A

A

C31H57NO7
1426535-84-3

C31H57NO7

B

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
Stage #1: siladenoserinol A With sodium hydroxide In methanol for 2h; Reflux;
Stage #2: With hydrogenchloride In water
phosphorylcholine chloride, calcium salt
4826-71-5

phosphorylcholine chloride, calcium salt

(R)-oxiranemethanol
57044-25-4

(R)-oxiranemethanol

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
Stage #1: phosphorylcholine chloride, calcium salt With sodium carbonate In water at 20℃; for 1h;
Stage #2: (R)-oxiranemethanol Reagent/catalyst; Concentration; Reflux;
289 g
C10H22NO7P

C10H22NO7P

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 5h; pH=1 - 2;45.2 g
C11H24NO7P

C11H24NO7P

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 5h; pH=1 - 2;45.3 g
(R)-2-(oxiran-2-ylmethoxy)-1,3,2-dioxaphospholane

(R)-2-(oxiran-2-ylmethoxy)-1,3,2-dioxaphospholane

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: oxygen / dichloromethane / 20 °C
2: ethanol / 8 h / 0 °C / Reflux
3: 717 type ion exchange resin / ethanol; water / 4 h / 0 °C
View Scheme
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

1-palmitoyl-sn-glycero-3-phosphocholine
17364-16-8, 17364-17-9, 17364-18-0, 14863-27-5

1-palmitoyl-sn-glycero-3-phosphocholine

Conditions
ConditionsYield
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Heating;
Stage #2: n-hexadecanoyl chloride With TEA In isopropyl alcohol at 25℃; for 0.25h; Further stages.;
97%
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Reflux;
Stage #2: n-hexadecanoyl chloride With triethylamine at 20℃; for 1h;
90%
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Heating;
Stage #2: n-hexadecanoyl chloride With TEA In isopropyl alcohol at 25℃; for 0.25h; Further stages.;
80%
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Reflux;
Stage #2: n-hexadecanoyl chloride With triethylamine In isopropyl alcohol at 25℃; for 0.25h;
80%
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol at 100℃; for 1h;
Stage #2: n-hexadecanoyl chloride With triethylamine In isopropyl alcohol at 20℃;
31%
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Stearoyl chloride
112-76-5

Stearoyl chloride

1-stearoyl-sn-glycero-3-phosphocholine
19420-57-6

1-stearoyl-sn-glycero-3-phosphocholine

Conditions
ConditionsYield
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Heating;
Stage #2: Stearoyl chloride With TEA In isopropyl alcohol at 20℃; for 0.583333h; Further stages.;
97%
With di(n-butyl)tin oxide; triethylamine70%
(Z)-9-octadecenoyl chloride
112-77-6

(Z)-9-octadecenoyl chloride

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

1-oleoyl-L-lysophosphatidylcholine
19420-56-5

1-oleoyl-L-lysophosphatidylcholine

Conditions
ConditionsYield
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Heating;
Stage #2: (Z)-9-octadecenoyl chloride With TEA In isopropyl alcohol at 20℃; for 0.583333h; Further stages.;
97%
n-dodecanoyl chloride
112-16-3

n-dodecanoyl chloride

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

LPC (12:0)
20559-18-6

LPC (12:0)

Conditions
ConditionsYield
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Heating;
Stage #2: n-dodecanoyl chloride With TEA In isopropyl alcohol at 20℃; for 0.583333h; Further stages.;
97%
aqueous cadmium chloride

aqueous cadmium chloride

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

sn-glycero-3-phosphocholine cadmium chloride complex

sn-glycero-3-phosphocholine cadmium chloride complex

Conditions
ConditionsYield
In methanol; water at 0℃; for 4h;91%
aqueous cadmium chloride

aqueous cadmium chloride

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

1-α-glycerophosphocholine cadmium chloride salt

1-α-glycerophosphocholine cadmium chloride salt

Conditions
ConditionsYield
In methanol; water91%
cis-Octadecenoic acid
112-80-1

cis-Octadecenoic acid

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

dioleoylphosphatidylcholine
4235-95-4

dioleoylphosphatidylcholine

Conditions
ConditionsYield
With dmap; Hyflo Super-Cel; dicyclohexyl-carbodiimide In chloroform at 30℃;90.3%
With dmap; dicyclohexyl-carbodiimide In chloroform at 20℃; for 12h; Reagent/catalyst; Solvent; Darkness;82.33%
triisopropylsilyl trifluoromethanesulfonate
80522-42-5

triisopropylsilyl trifluoromethanesulfonate

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

C17H40NO6PSi

C17H40NO6PSi

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere; regioselective reaction;87%
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Stearoyl chloride
112-76-5

Stearoyl chloride

1-stearoyl-2-lyso-sn-glycero-3-phosphocholine
19420-57-6

1-stearoyl-2-lyso-sn-glycero-3-phosphocholine

Conditions
ConditionsYield
Stage #1: L-glycero-3-phosphorylcholine; Stearoyl chloride With di(n-butyl)tin oxide In ethanol for 0.5h; Reflux;
Stage #2: Stearoyl chloride With triethylamine In tetrahydrofuran at 50℃; for 3h;
83.3%
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

2-[[[(carboxymethyl)oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium
853798-56-8

2-[[[(carboxymethyl)oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium

Conditions
ConditionsYield
With ruthenium trichloride; sodium periodate; water In acetonitrile at 0℃;82%
With ruthenium trichloride; sodium periodate In water at 20℃; for 2h; Product distribution / selectivity; Cooling in ice-water bath;
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

butyryl chloride
141-75-3

butyryl chloride

C12H26NO7P

C12H26NO7P

Conditions
ConditionsYield
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Heating;
Stage #2: butyryl chloride With dmap In isopropyl alcohol at 25℃; for 48h; Further stages.;
82%
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

L-dipalmitoylphosphatidylcholine
63-89-8

L-dipalmitoylphosphatidylcholine

Conditions
ConditionsYield
With dmap; Hyflo Supre-Cel; dicyclohexyl-carbodiimide In chloroform at 30℃;80%
Stage #1: L-glycero-3-phosphorylcholine; 1-hexadecylcarboxylic acid With dmap In dichloromethane for 0.333333h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane for 8h;
80.3%
Stage #1: 1-hexadecylcarboxylic acid With 1,1'-carbonyldiimidazole In chloroform-d1 at 20℃; for 0.75h; Condensation;
Stage #2: L-glycero-3-phosphorylcholine With 1,8-diazabicyclo[5.4.0]undec-7-ene In chloroform-d1 at 20℃; for 24h; Acylation;
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

n-valeryl chloride
638-29-9

n-valeryl chloride

C13H28NO7P

C13H28NO7P

Conditions
ConditionsYield
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Heating;
Stage #2: n-valeryl chloride With dmap In isopropyl alcohol at 25℃; for 48h; Further stages.;
80%
3-(tritylthio) propanoic acid
27144-18-9

3-(tritylthio) propanoic acid

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

bis(tritylmercaptopropionate)glycerophosphorylcholine

bis(tritylmercaptopropionate)glycerophosphorylcholine

Conditions
ConditionsYield
Stage #1: 3-(tritylthio) propanoic acid With 1,1'-carbonyldiimidazole In dimethyl sulfoxide for 2h;
Stage #2: L-glycero-3-phosphorylcholine With 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 20℃;
80%
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole In dimethyl sulfoxide at 20℃; for 6h; Time;
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

1,2-α-eleostearoyl-sn-glycero-3-phosphocholine

1,2-α-eleostearoyl-sn-glycero-3-phosphocholine

Conditions
ConditionsYield
With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide In chloroform for 20h;77%
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

Hexanoyl chloride
142-61-0

Hexanoyl chloride

L-alpha-caproyl lysophosphatidylcholine
58445-96-8

L-alpha-caproyl lysophosphatidylcholine

Conditions
ConditionsYield
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Heating;
Stage #2: Hexanoyl chloride With dmap In isopropyl alcohol at 25℃; for 48h; Further stages.;
75%
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

6-((1,1-dimethylethyl)diphenylsilyloxy)hexanoic acid
122846-05-3

6-((1,1-dimethylethyl)diphenylsilyloxy)hexanoic acid

C52H76NO10PSi2

C52H76NO10PSi2

Conditions
ConditionsYield
Stage #1: 6-((1,1-dimethylethyl)diphenylsilyloxy)hexanoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 35℃; for 4h;
Stage #2: L-glycero-3-phosphorylcholine With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; dimethyl sulfoxide at 20 - 40℃; for 20h;
71%
tetradecylthioacetic Acid
2921-20-2

tetradecylthioacetic Acid

L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

1,2-di-[2-(tetradecylthio)acetyl]-sn-glycero-3-phosphocholine
636589-28-1

1,2-di-[2-(tetradecylthio)acetyl]-sn-glycero-3-phosphocholine

Conditions
ConditionsYield
Stage #1: tetradecylthioacetic Acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 2.75h; Inert atmosphere;
Stage #2: L-glycero-3-phosphorylcholine With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; dimethyl sulfoxide at 20℃; for 16h; Inert atmosphere;
70%
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

3-O-acetylbetulinic acid chloride
59868-82-5

3-O-acetylbetulinic acid chloride

1-acetylbetulinyl-Sn-glycero-3-phosphocholine

1-acetylbetulinyl-Sn-glycero-3-phosphocholine

Conditions
ConditionsYield
Stage #1: L-glycero-3-phosphorylcholine With di(n-butyl)tin oxide In isopropyl alcohol for 1h; Reflux;
Stage #2: 3-O-acetylbetulinic acid chloride With triethylamine In isopropyl alcohol at 20℃; for 5h;
69%
L-glycero-3-phosphorylcholine
28319-77-9

L-glycero-3-phosphorylcholine

trityl chloride
76-83-5

trityl chloride

1-O-trityl-sn-glycero-3-phosphocholine
103675-56-5

1-O-trityl-sn-glycero-3-phosphocholine

Conditions
ConditionsYield
With zinc(II) chloride In N,N-dimethyl-formamide at 5℃; for 10h;67%
With zinc(II) chloride In N,N-dimethyl-formamide at 5℃;51.2%
Stage #1: L-glycero-3-phosphorylcholine With zinc(II) chloride In N,N-dimethyl-formamide at 4℃; for 0.5h;
Stage #2: trityl chloride In N,N-dimethyl-formamide at 4℃;
50%

28319-77-9Relevant articles and documents

Urakami,Okura

, p. 779 (1958)

Preparation method of glycerophosphocholine

-

Paragraph 0028-0032; 0033-0037; 0038-0042; 0043-0047, (2021/09/08)

The invention discloses a preparation method of glycerophosphocholine, which comprises the following steps: 1, dissolving lecithin in an alcohol solvent, then adding inorganic base or organic base for hydrolysis reaction to obtain a reaction solution, filtering, adding acid into the filtrate to adjust the pH value, and drying the alcohol solvent by distillation under reduced pressure to obtain a compound (I); 2, dissolving the compound (I) in water, and adding an extraction solvent for extraction to obtain a compound (II); and 3, carrying out active carbon decoloration on the compound (II) through a water phase, directly stirring by using mixed anion-cation resin, drying by distillation, and adding a recrystallization solvent to carry out recrystallization reaction to obtain refined glycerophosphocholine. According to the invention, lecithin is hydrolyzed in an alcohol solvent by using an inorganic weak base through a chemical hydrolysis method, and glycerophosphocholine which is very high in purity and reaches a medicinal level is obtained through a series of simple post-treatment processes, and the production process is simple, easy to control, low in material cost and suitable for industrial production of glycerophosphocholine.

Synthesis method for compound choline alfoscerate for promoting brain functions

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Paragraph 0023-0024; 0026-0028, (2019/11/21)

The invention discloses a synthesis method for a compound choline alfoscerate for promoting brain functions. The synthesis method comprises the following steps: (1) enabling calcium phosphorylcholinechloride to react with oxalic acid to generate precipitate of phosphorylcholine chloride and oxalic acid; (2) enabling the phosphorylcholine chloride prepared in the step (1) to react with an alkali in a solvent so as to obtain a salt of the phosphorylcholine chloride; and (3) enabling the salt of the phosphorylcholine chloride to react with propylene glycol, so as to obtain choline alfoscerate. Raw materials of the synthesis method for the compound choline alfoscerate for promoting brain functions are low in price, low in cost and easy to obtain, the synthesis method is short in synthesis path and high in yield, the obtained product is high in chemical purity, all reactions need no special production equipment, the obtained intermediate and final products need no column chromatography orcrystallization purification, the production cost can be lowered, industrial amplified production can be facilitated, a high-purity product can be provided for the market, and thus high economic benefits can be met.

Preparation method of L-alpha-glycerophosphorylcholine

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Paragraph 0035; 0037; 0046; 0048; 0049; 0056-0058, (2019/01/08)

The invention relates to the field of L-alpha-glycerophosphorylcholine and particularly relates to a preparation method of high-purity L-alpha-glycerophosphorylcholine. The preparation method uses glycidol as a raw material to prepare L-alpha-glycerophosphorylcholine. The preparation method comprises: preparing 2-chloro-1, 3, 2-dioxaphospholane from phosphorus trichloride and ethylene glycol, carrying out oxidization, adding trimethylamine and dioxaphospholane for a reaction, adding an acid into the reaction system, carrying out ring opening oxidization to obtain L-alpha-glycerophosphorylcholine chloride, and adding resin into the L-alpha-glycerophosphorylcholine chloride to remove chloride ions so that a finished product is obtained. The preparation method has the advantages of mild reaction conditions, short reaction time, easy availability of raw materials, simple post-treatment and high product purity.

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