Journal of Medicinal Chemistry p. 2645 - 2657 (1993)
Update date:2022-08-05
Topics: Potent Conformationally restricted
Clark
Miller
Berger
Repke
Weinhardt
Kowalczyk
Eglen
Bonhaus
Lee
Michel
Smith
Wong
Several series of N-(quinuclidin-3-yl)aryl and heteroaryl-fused pyridones were synthesized and evaluated for 5-HT3 receptor affinity. In the heteroaryl series,2-(quinuclidin-3-yl)tetrahydropyrido[4,3-b]indol-1-one (8a) and the 4,5-alkano-bridge
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